对评论的回应：接受三联或二联抑制性抗逆转录病毒疗法个体中炎症生物标志物的长期变化 - Suppr

Response to Commentary: Long-term Changes of Inflammatory Biomarkers in Individuals on Suppressive Three-Drug or Two-Drug Antiretroviral Regimens.

作者信息

Serrano-Villar Sergio, Moreno Santiago

机构信息

Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, Spain.

CIBER de Enfermedades Infecciosas (CIBERInfec), Instituto de Salud Carlos III, Madrid, Spain.

出版信息

Front Immunol. 2022 Jun 3;13:923905. doi: 10.3389/fimmu.2022.923905. eCollection 2022.

DOI:10.3389/fimmu.2022.923905

PMID:35720404

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9203683/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a63/9203683/3adbd60b9753/fimmu-13-923905-g001.jpg

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Response to Commentary: Long-term Changes of Inflammatory Biomarkers in Individuals on Suppressive Three-Drug or Two-Drug Antiretroviral Regimens.对评论的回应：接受三联或二联抑制性抗逆转录病毒疗法个体中炎症生物标志物的长期变化

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Commentary: Long-Term Changes of Inflammatory Biomarkers in Individuals on Suppressive Three-Drug or Two-Drug Antiretroviral Regimens.评论：接受三联或二联抗逆转录病毒抑制治疗方案的个体中炎症生物标志物的长期变化

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Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy.秘鲁感染HIV的男性和女性在接受抑制性抗逆转录病毒治疗之前及期间的炎症生物标志物。

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Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death.在开始抗逆转录病毒治疗（ART）之前，CRP、D-二聚体、IL-6 和透明质酸水平较高与艾滋病或死亡风险增加相关。

J Infect Dis. 2011 Jun 1;203(11):1637-46. doi: 10.1093/infdis/jir134.

Brief Report: Changes in Levels of Inflammation After Antiretroviral Treatment During Early HIV Infection in AIDS Clinical Trials Group Study A5217.简短报告：艾滋病临床试验组A5217研究中早期HIV感染抗逆转录病毒治疗后炎症水平的变化

J Acquir Immune Defic Syndr. 2017 May 1;75(1):137-141. doi: 10.1097/QAI.0000000000001320.

Switching to dual antiretroviral regimens is associated with improvement or no changes in activation and inflammation markers in virologically suppressed HIV-1-infected patients: the TRILOBITHE pilot study.切换至双重抗逆转录病毒治疗方案与病毒学抑制的 HIV-1 感染患者的激活和炎症标志物的改善或无变化相关：TRILOBITHE 初步研究。

HIV Med. 2019 Sep;20(8):555-560. doi: 10.1111/hiv.12749. Epub 2019 May 26.

Vitamin D Levels and Markers of Inflammation and Metabolism in HIV-Infected Individuals on Suppressive Antiretroviral Therapy.接受抑制性抗逆转录病毒治疗的HIV感染者的维生素D水平以及炎症和代谢标志物

AIDS Res Hum Retroviruses. 2016 Mar;32(3):247-54. doi: 10.1089/aid.2015.0200. Epub 2015 Nov 16.

d-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS.在发生 IRIS 的患者中，在开始抗逆转录病毒治疗之前，d-二聚体和 CRP 水平升高。

Clin Immunol. 2010 Jul;136(1):42-50. doi: 10.1016/j.clim.2010.02.010. Epub 2010 Mar 15.

Risk Factors of Hypovitaminosis D in HIV-Infected Patients on Suppressive Antiretroviral Therapy.HIV 感染者接受抑制性抗逆转录病毒治疗后发生维生素 D 缺乏症的危险因素。

AIDS Res Hum Retroviruses. 2020 Aug;36(8):676-680. doi: 10.1089/AID.2019.0020. Epub 2020 Jun 8.

本文引用的文献

Front Immunol. 2022 Apr 29;13:904689. doi: 10.3389/fimmu.2022.904689. eCollection 2022.

Front Immunol. 2022 Mar 31;13:873408. doi: 10.3389/fimmu.2022.873408. eCollection 2022.

Front Immunol. 2022 Mar 14;13:848630. doi: 10.3389/fimmu.2022.848630. eCollection 2022.

Efficacy and Safety of Switching to the 2-Drug Regimen Dolutegravir/Lamivudine Versus Continuing a 3- or 4-Drug Regimen for Maintaining Virologic Suppression in Adults Living With Human Immunodeficiency Virus 1 (HIV-1): Week 48 Results From the Phase 3, Noninferiority SALSA Randomized Trial.在成人人类免疫缺陷病毒 1（HIV-1）感染者中，转换为二药方案多替拉韦/拉米夫定与继续三药或四药方案维持病毒学抑制的疗效和安全性：来自 III 期非劣效性 SALSA 随机试验的第 48 周结果。

Clin Infect Dis. 2023 Feb 18;76(4):720-729. doi: 10.1093/cid/ciac130.

Efficacy and Safety of Switching to Dolutegravir/Lamivudine Versus Continuing a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Results Through Week 144 From the Phase 3, Noninferiority TANGO Randomized Trial.在成人人类免疫缺陷病毒 1 型感染者中，转换为多替拉韦/拉米夫定与继续使用替诺福韦艾拉酚胺为基础的三或四药物方案维持病毒学抑制的疗效和安全性：来自 3 期非劣效性 TANGO 随机试验的第 144 周结果。

Clin Infect Dis. 2022 Sep 29;75(6):975-986. doi: 10.1093/cid/ciac036.

Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV.从增效蛋白酶抑制剂转换为多替拉韦可降低高心血管风险 HIV 感染者的可溶性 CD14 和脂联素。

J Antimicrob Chemother. 2021 Aug 12;76(9):2380-2393. doi: 10.1093/jac/dkab158.

Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort Study.在病毒学抑制的HIV感染者中，抗逆转录病毒治疗不完全依从性与心血管事件及死亡率的关联：瑞士HIV队列研究

Open Forum Infect Dis. 2021 Jan 21;8(2):ofab032. doi: 10.1093/ofid/ofab032. eCollection 2021 Feb.

Clinical Outcomes of 2-Drug Regimens vs 3-Drug Regimens in Antiretroviral Treatment-Experienced People Living With Human Immunodeficiency Virus.抗逆转录病毒治疗后艾滋病毒感染者的 2 药方案与 3 药方案的临床结局。

Clin Infect Dis. 2021 Oct 5;73(7):e2323-e2333. doi: 10.1093/cid/ciaa1878.

Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study.一线抗逆转录病毒疗法对 CoRIS 中 CD4/CD8 比值和 CD8 细胞计数的影响：一项前瞻性多中心队列研究。

Lancet HIV. 2020 Aug;7(8):e565-e573. doi: 10.1016/S2352-3018(20)30202-2.

Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study.在 START 研究中达到病毒学抑制的个体中，不完全 ART 依从性与更高的炎症相关。

J Int AIDS Soc. 2019 Jun;22(6):e25297. doi: 10.1002/jia2.25297.

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Response to Commentary: Long-term Changes of Inflammatory Biomarkers in Individuals on Suppressive Three-Drug or Two-Drug Antiretroviral Regimens.

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