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进行性双下肢轻瘫:神经结节病的诊断难题

Worsening Paraparesis: A Diagnostic Dilemma for Neurosarcoidosis.

作者信息

Stroia Alexandra, Priyadarshini Shista, Meseeha Marcelle

机构信息

Internal Medicine, Guthrie Robert Packer Hospital, Sayre, USA.

Internal Medicine, Lake Erie College of Osteopathic Medicine, Erie, USA.

出版信息

Cureus. 2022 Jun 15;14(6):e25958. doi: 10.7759/cureus.25958. eCollection 2022 Jun.

Abstract

Sarcoidosis is a chronic granulomatous disorder mostly known to affect the respiratory system. However, about 5-10% of cases develop neurological complications, either de novo or in patients with known sarcoidosis. The most common complications as cited by current literature include cranial nerve palsies, meningitis, and myelopathy. A unilateral thalamic lesion is an extremely rare presentation of disease. As the neurological manifestations of sarcoidosis are uncommon and variable, it poses a diagnostic challenge. We present a challenging case with worsening paraparesis and a step-by-step approach to how it was diagnosed as neurosarcoidosis. We aimed to create awareness about this uncommon manifestation to avoid misdiagnosis and promote early recognition of neurosarcoidosis.

摘要

结节病是一种慢性肉芽肿性疾病,主要累及呼吸系统。然而,约5%-10%的病例会出现神经系统并发症,可为新发,也可发生于已知患有结节病的患者。当前文献中提及的最常见并发症包括颅神经麻痹、脑膜炎和脊髓病。单侧丘脑病变是该病极为罕见的表现形式。由于结节病的神经系统表现不常见且多变,因此构成了诊断挑战。我们报告一例具有挑战性的病例,患者双下肢轻瘫症状加重,并介绍了如何逐步诊断为神经结节病的过程。我们旨在提高对这种罕见表现的认识,以避免误诊并促进对神经结节病的早期识别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/316f/9203248/671e7f338866/cureus-0014-00000025958-i01.jpg

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