Stroia Alexandra, Priyadarshini Shista, Meseeha Marcelle
Internal Medicine, Guthrie Robert Packer Hospital, Sayre, USA.
Internal Medicine, Lake Erie College of Osteopathic Medicine, Erie, USA.
Cureus. 2022 Jun 15;14(6):e25958. doi: 10.7759/cureus.25958. eCollection 2022 Jun.
Sarcoidosis is a chronic granulomatous disorder mostly known to affect the respiratory system. However, about 5-10% of cases develop neurological complications, either de novo or in patients with known sarcoidosis. The most common complications as cited by current literature include cranial nerve palsies, meningitis, and myelopathy. A unilateral thalamic lesion is an extremely rare presentation of disease. As the neurological manifestations of sarcoidosis are uncommon and variable, it poses a diagnostic challenge. We present a challenging case with worsening paraparesis and a step-by-step approach to how it was diagnosed as neurosarcoidosis. We aimed to create awareness about this uncommon manifestation to avoid misdiagnosis and promote early recognition of neurosarcoidosis.
结节病是一种慢性肉芽肿性疾病,主要累及呼吸系统。然而,约5%-10%的病例会出现神经系统并发症,可为新发,也可发生于已知患有结节病的患者。当前文献中提及的最常见并发症包括颅神经麻痹、脑膜炎和脊髓病。单侧丘脑病变是该病极为罕见的表现形式。由于结节病的神经系统表现不常见且多变,因此构成了诊断挑战。我们报告一例具有挑战性的病例,患者双下肢轻瘫症状加重,并介绍了如何逐步诊断为神经结节病的过程。我们旨在提高对这种罕见表现的认识,以避免误诊并促进对神经结节病的早期识别。