Tang Qianyu, Zeng Min, Chen Linxi, Fu Nian
Department of Gastroenterology, The Affiliated Nanhua Hospital, Hunan Provincial Clinical Research Center of Metabolic Associated Fatty Liver Disease, Hengyang Medical School, University of South China, Hengyang, China.
Department of Gastroenterology, Liuyang Hospital of Chinese Medicine, Changsha, China.
Front Pharmacol. 2022 Jun 2;13:871100. doi: 10.3389/fphar.2022.871100. eCollection 2022.
Thyroid hormone/thyroid hormone receptor (TH/TR) axis is characterized by TH with the assistance of plasma membrane transporters to combine with TR and mediate biological activities. Growing evidence suggests that TH/TR participates in plenty of hepatic metabolism. Thus, this review focuses on the role of the TH/TR axis in the liver diseases. To be specific, the TH/TR axis may improve metabolic-associated fatty liver disease, hepatitis, liver fibrosis, and liver injury while exacerbating the progression of acute liver failure and alcoholic liver disease. Also, the TH/TR axis has paradoxical roles in hepatocellular carcinoma. The TH/TR axis may be a prospecting target to cure hepatic diseases.
甲状腺激素/甲状腺激素受体（TH/TR）轴的特点是甲状腺激素在质膜转运蛋白的协助下与甲状腺激素受体结合并介导生物学活性。越来越多的证据表明，TH/TR参与大量肝脏代谢过程。因此，本综述聚焦于TH/TR轴在肝脏疾病中的作用。具体而言，TH/TR轴可能改善代谢相关脂肪性肝病、肝炎、肝纤维化和肝损伤，同时加剧急性肝衰竭和酒精性肝病的进展。此外，TH/TR轴在肝细胞癌中具有矛盾的作用。TH/TR轴可能是治疗肝脏疾病的一个有前景的靶点。
