Vicente-Acosta Andrés, Ceprian Maria, Sobrino Pilar, Pazos Maria Ruth, Loría Frida
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain.
Front Pharmacol. 2022 Jun 1;13:888222. doi: 10.3389/fphar.2022.888222. eCollection 2022.
Stroke is the second leading cause of death worldwide following coronary heart disease. Despite significant efforts to find effective treatments to reduce neurological damage, many patients suffer from sequelae that impair their quality of life. For this reason, the search for new therapeutic options for the treatment of these patients is a priority. Glial cells, including microglia, astrocytes and oligodendrocytes, participate in crucial processes that allow the correct functioning of the neural tissue, being actively involved in the pathophysiological mechanisms of ischemic stroke. Although the exact mechanisms by which glial cells contribute in the pathophysiological context of stroke are not yet completely understood, they have emerged as potentially therapeutic targets to improve brain recovery. The endocannabinoid system has interesting immunomodulatory and protective effects in glial cells, and the pharmacological modulation of this signaling pathway has revealed potential neuroprotective effects in different neurological diseases. Therefore, here we recapitulate current findings on the potential promising contribution of the endocannabinoid system pharmacological manipulation in glial cells for the treatment of ischemic stroke.
中风是继冠心病之后全球第二大死因。尽管人们为寻找有效治疗方法以减少神经损伤付出了巨大努力，但许多患者仍患有影响其生活质量的后遗症。因此，为这些患者寻找新的治疗选择是当务之急。神经胶质细胞，包括小胶质细胞、星形胶质细胞和少突胶质细胞，参与神经组织正常运作的关键过程，并积极参与缺血性中风的病理生理机制。尽管神经胶质细胞在中风病理生理背景下发挥作用的确切机制尚未完全明确，但它们已成为改善脑恢复的潜在治疗靶点。内源性大麻素系统在神经胶质细胞中具有有趣的免疫调节和保护作用，对该信号通路的药理学调节已在不同神经疾病中显示出潜在的神经保护作用。因此，在此我们概述了内源性大麻素系统药理学操纵在神经胶质细胞中对缺血性中风治疗潜在的有前景贡献的当前研究结果。
