Ju Hyun Jeong, Park Hyo Jin, Choi In Hye, Lee Kyung Ho, Kwon Mi Yeon, Park Chul Jong
Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Department of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
Ann Dermatol. 2022 Jun;34(3):200-205. doi: 10.5021/ad.2022.34.3.200. Epub 2022 May 20.
The phenotypic heterogeneity of psoriasis is suspected to reflect differences in its pathogenesis, but not yet completely elucidated. Studies of the Th1 and Th17 cytokines associated with different phenotypes of psoriasis have yielded inconsistent results.
To investigate the tissue expression levels of Th1 and Th17 cytokines among patients with chronic plaque psoriasis, acute guttate psoriasis, and healthy control.
A total of 20 patients with psoriasis (10 with chronic plaque type and 10 with acute guttate type) and 5 healthy controls were enrolled. The tissue mRNA and protein levels of following cytokines were measured: interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22.
The tissue mRNA levels of IL-12, IFN-γ, IL-23, IL-17A, IL-22 and the protein levels of IL-12, IL-2, IFN-γ, IL-17A, IL-22 were significantly increased in the psoriasis patients compared with the healthy controls. In comparisons of the subtypes, the tissue mRNA level of IFN-γ was increased in acute guttate psoriasis, whereas the protein levels of IL-12 and IL-17A were significantly increased in chronic plaque psoriasis. The cytokine ratios of IL-17A/IL-2 and IL-22/IL-2 were significantly higher in chronic plaque psoriasis than in acute guttate psoriasis.
We confirmed that the tissue levels of Th1 and Th17 cytokines were increased in psoriasis patients compared with healthy controls. The increased IFN-γ mRNA level in acute guttate psoriasis and increased IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.
银屑病的表型异质性被怀疑反映了其发病机制的差异，但尚未完全阐明。对与银屑病不同表型相关的Th1和Th17细胞因子的研究结果并不一致。
研究慢性斑块状银屑病、急性点滴状银屑病患者及健康对照者中Th1和Th17细胞因子的组织表达水平。
共纳入20例银屑病患者（10例慢性斑块型和10例急性点滴型）及5例健康对照者。检测以下细胞因子的组织mRNA和蛋白水平：白细胞介素（IL）-12、IL-2、干扰素（IFN）-γ、IL-23、IL-17A和IL-22。
与健康对照相比，银屑病患者的IL-12、IFN-γ、IL-23、IL-17A、IL-22组织mRNA水平及IL-12、IL-2、IFN-γ、IL-17A、IL-22蛋白水平显著升高。在各亚型比较中，急性点滴状银屑病中IFN-γ的组织mRNA水平升高，而慢性斑块状银屑病中IL-12和IL-17A的蛋白水平显著升高。慢性斑块状银屑病中IL-17A/IL-2和IL-22/IL-2的细胞因子比值显著高于急性点滴状银屑病。
我们证实，与健康对照相比，银屑病患者的Th1和Th17细胞因子组织水平升高。急性点滴状银屑病中IFN-γ mRNA水平升高以及慢性斑块状银屑病中IL-12和IL-17A蛋白水平升高表明，Th1和Th17细胞因子之间的失衡可能在银屑病的表型转变中起作用。
