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Childhood guttate psoriasis: an updated review.

作者信息

Leung Alexander Kc, Barankin Benjamin, Lam Joseph M, Leong Kin Fon

机构信息

Department of Pediatrics, The University of Calgary, Calgary, Alberta, Canada.

The Alberta Children's Hospital, Calgary, Alberta, Canada.

出版信息

Drugs Context. 2023 Oct 23;12. doi: 10.7573/dic.2023-8-2. eCollection 2023.


DOI:10.7573/dic.2023-8-2
PMID:37908643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10615329/
Abstract

BACKGROUND: Guttate psoriasis is common and affects 0.5-2% of individuals in the paediatric age group. This review aims to familiarize physicians with the clinical manifestations, evaluation, diagnosis and proper management of guttate psoriasis. METHODS: A search was conducted in July 2023 in PubMed Clinical Queries using the key term "guttate psoriasis". The search strategy included all observational studies, clinical trials and reviews published within the past 10 years. The information retrieved from the search was used in the compilation of the present article. RESULTS: Guttate psoriasis typically presents with an abrupt onset of numerous, small, scattered, tear-drop-shaped, scaly, erythematous, pruritic papules and plaques. Sites of predilection include the trunk and proximal extremities. There may be a history of preceding streptococcal infection. Koebner phenomenon is characteristic. Guttate psoriasis may spontaneously remit within 3-4 months with no residual scarring, may intermittently recur and, in 40-50% of cases, may persist and progress to chronic plaque psoriasis. Given the possibility for spontaneous remission within several months, active treatment may not be necessary except for cosmetic purposes or because of pruritus. On the other hand, given the high rates of persistence of guttate psoriasis and progression to chronic plaque psoriasis, some authors suggest active treatment of this condition. CONCLUSION: Various treatment options are available for guttate psoriasis. Triggering and exacerbating factors should be avoided if possible. Topical corticosteroids alone or in combination with other topical agents (e.g. tazarotene and vitamin D analogues) are the most rapid and efficient treatment for guttate psoriasis and are therefore the first-line treatment for mild cases. Other topical therapies include vitamin D analogues, calcineurin inhibitors, anthralin, coal tar and tazarotene. Ultraviolet phototherapy is the first-line therapy for moderate-to-severe guttate psoriasis, as it is more practical than topical therapy when treating widespread or numerous small lesions. Systemic immunosuppressive and immunomodulatory therapies (e.g. methotrexate, cyclosporine, retinoids, fumaric acid esters and biologics) may be considered for patients with moderate-to-severe guttate psoriasis who fail to respond to phototherapy and topical therapies.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/1f0ad4614cfe/dic-2023-8-2_LEUNG_figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/8e6aca70eaf0/dic-2023-8-2_LEUNG_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/8b6a8fd1184d/dic-2023-8-2_LEUNG_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/54263364e099/dic-2023-8-2_LEUNG_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/787e9326255f/dic-2023-8-2_LEUNG_figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/1f0ad4614cfe/dic-2023-8-2_LEUNG_figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/8e6aca70eaf0/dic-2023-8-2_LEUNG_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/8b6a8fd1184d/dic-2023-8-2_LEUNG_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/54263364e099/dic-2023-8-2_LEUNG_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/787e9326255f/dic-2023-8-2_LEUNG_figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e716/10615329/1f0ad4614cfe/dic-2023-8-2_LEUNG_figure5.jpg

相似文献

[1]
Childhood guttate psoriasis: an updated review.

Drugs Context. 2023-10-23

[2]
Non-antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis.

Cochrane Database Syst Rev. 2019-4-8

[3]
Resolution of Guttate Psoriasis Plaques After One-time Administration of Guselkumab.

J Drugs Dermatol. 2019-8-1

[4]
Therapy of moderate and severe psoriasis.

GMS Health Technol Assess. 2006-4-26

[5]
Childhood psoriasis.

Indian J Dermatol Venereol Leprol. 2010

[6]
Management of Guttate Psoriasis: A Systematic Review.

J Cutan Med Surg. 2024

[7]
Antistreptococcal interventions for guttate and chronic plaque psoriasis.

Cochrane Database Syst Rev. 2019-3-5

[8]
Psoriasis in children: a guide to its diagnosis and management.

Paediatr Drugs. 2001

[9]
[Narrow-band UVB therapy in psoriasis vulgaris: good practice guideline and recommendations of the French Society of Photodermatology].

Ann Dermatol Venereol. 2010-1

[10]
[Topical corticosteroids and corticosteroid sparing therapy in psoriasis management].

Acta Med Croatica. 2007-9

引用本文的文献

[1]
Systemic Psoriasis: From Molecular Mechanisms to Global Management Strategies.

Clin Rev Allergy Immunol. 2025-8-7

[2]
From Infection to Autoimmunity: as a Model Pathogen.

Microorganisms. 2025-6-16

[3]
[Onychomycosis in children and adolescents-case report and overview of the literature].

Dermatologie (Heidelb). 2025-5

[4]
Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen.

Pharmaceutics. 2025-2-20

[5]
A Rare Case of Juvenile Psoriatic Arthritis.

Cureus. 2024-11-4

[6]
Functional Genomics and Insights into the Pathogenesis and Treatment of Psoriasis.

Biomolecules. 2024-5-3

[7]
Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles.

Pharmaceutics. 2024-3-25

本文引用的文献

[1]
Persistence and effectiveness of guselkumab treatment in patients with moderate-to-severe plaque psoriasis in a non-interventional real-world setting: The SPRING study.

J Eur Acad Dermatol Venereol. 2025-3

[2]
Brodalumab in the Treatment of Plaque Psoriasis Localized in Difficult-to-Treat Areas: A Narrative Review.

Dermatol Pract Concept. 2023-7-1

[3]
Tildrakizumab in Combination With Topical Halcinonide 0.1% Ointment for Treating Moderate to Severe Plaque Psoriasis.

J Drugs Dermatol. 2023-8-1

[4]
Group A β-hemolytic Streptococcal Pharyngitis: An Updated Review.

Curr Pediatr Rev. 2024

[5]
Educational service correlates with greater improvement and adherence in psoriasis patients responding to ixekizumab.

J Dtsch Dermatol Ges. 2023-8

[6]
Effectiveness and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis in real-world practice.

Exp Dermatol. 2024-1

[7]
Brodalumab for the treatment of plaque psoriasis in a real-life setting: a 3 years multicenter retrospective study-IL PSO (Italian landscape psoriasis).

Front Med (Lausanne). 2023-7-3

[8]
Ixekizumab Real-World Effectiveness at 24 Weeks in Patients with Psoriasis: Data from the United States Taltz Customer Support Program.

Dermatol Ther (Heidelb). 2023-8

[9]
Presentations of Cutaneous Disease in Various Skin Pigmentations: Inverse Psoriasis.

HCA Healthc J Med. 2022-6-28

[10]
Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

Clin Cosmet Investig Dermatol. 2023-6-28

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