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Current update on anticancer effects of icariin: A journey of the last ten years.

作者信息

Gupta Mukta, Mishra Yachana, Mishra Vijay, Tambuwala Murtaza M

机构信息

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab)-144411, India.

Department of Zoology, Shri Shakti Degree College, Sankhahari, Ghatampur,Kanpur Nagar (UP)-209206, India.

出版信息

EXCLI J. 2022 Apr 6;21:680-686. doi: 10.17179/excli2022-4848. eCollection 2022.

DOI:10.17179/excli2022-4848
PMID:35721576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9203989/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/9203989/136981698a6d/EXCLI-21-680-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/9203989/5cdeee2004a1/EXCLI-21-680-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/9203989/136981698a6d/EXCLI-21-680-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/9203989/5cdeee2004a1/EXCLI-21-680-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/9203989/136981698a6d/EXCLI-21-680-g-001.jpg

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Current update on anticancer effects of icariin: A journey of the last ten years.淫羊藿苷抗癌作用的最新进展：过去十年的历程
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Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways.淫羊藿苷通过 PI3K/AKT 和 STAT3 通路抑制 KYSE70 人食管癌细胞的生长和转移。
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Icariin regulates the proliferation and apoptosis of human ovarian cancer cells through microRNA-21 by targeting PTEN, RECK and Bcl-2.淫羊藿苷通过靶向PTEN、RECK和Bcl-2，经由微小RNA-21调控人卵巢癌细胞的增殖和凋亡。
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Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway.淫羊藿苷通过靶向mTOR/PI3K/AKT信号通路诱导细胞凋亡和自噬，从而抑制人宫颈癌细胞的生长。
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Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities.淫羊藿苷通过增强p53活性来降低人结肠癌细胞的生长和转移。
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Anti-proliferative and cytoskeleton-disruptive effects of icariin on HepG2 cells.淫羊藿苷对肝癌细胞HepG2的抗增殖及细胞骨架破坏作用
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本文引用的文献

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Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells.一种载有淫羊藿苷的双分子层脂质体-蜂毒肽制剂的研发，其对胰腺癌细胞的抗癌活性有所提高。
Pharmaceuticals (Basel). 2021 Dec 15;14(12):1309. doi: 10.3390/ph14121309.
2
Development and Evaluation of Icariin-Loaded PLGA-PEG Nanoparticles for Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells.淫羊藿苷载 PLGA-PEG 纳米粒的制备及评价增强胰腺癌细胞促凋亡活性的研究。
AAPS PharmSciTech. 2021 Oct 19;22(8):252. doi: 10.1208/s12249-021-02111-w.
3
Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF-κB and PI3K/AKT pathways.
淫羊藿苷通过抑制NF-κB和PI3K/AKT信号通路抑制口腔鳞状细胞癌细胞增殖并诱导其凋亡。
Exp Ther Med. 2021 Sep;22(3):942. doi: 10.3892/etm.2021.10374. Epub 2021 Jul 1.
4
Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways.淫羊藿苷通过抑制TLR4/MyD88/NF-κB和Wnt/β-连环蛋白信号通路对宫颈癌炎症、凋亡、侵袭及肿瘤免疫的影响
Cancer Cell Int. 2021 Apr 13;21(1):206. doi: 10.1186/s12935-021-01910-2.
5
Icariin-induced inhibition of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer.淫羊藿素通过抑制 SIRT6/NF-κB 触发氧化还原介导的细胞凋亡并增强三阴性乳腺癌的抗肿瘤免疫。
Cancer Sci. 2020 Nov;111(11):4242-4256. doi: 10.1111/cas.14648. Epub 2020 Oct 7.
6
Study on the regulatory mechanism and experimental verification of icariin for the treatment of ovarian cancer based on network pharmacology.基于网络药理学的淫羊藿苷治疗卵巢癌的调控机制及实验验证研究。
J Ethnopharmacol. 2020 Nov 15;262:113189. doi: 10.1016/j.jep.2020.113189. Epub 2020 Jul 28.
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Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells.优化后的淫羊藿苷磷脂复合物在卵巢癌细胞中表现出增强的细胞毒性和诱导凋亡活性。
Pharmaceutics. 2020 Apr 11;12(4):346. doi: 10.3390/pharmaceutics12040346.
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Int J Oncol. 2020 Mar;56(3):821-834. doi: 10.3892/ijo.2020.4970. Epub 2020 Jan 24.
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Pharmacological effects of icariin.淫羊藿苷的药理作用。
Adv Pharmacol. 2020;87:179-203. doi: 10.1016/bs.apha.2019.10.004. Epub 2020 Jan 13.
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Onco Targets Ther. 2020 Jan 10;13:299-307. doi: 10.2147/OTT.S214514. eCollection 2020.