Department of Microbiology and Biochemical Pharmacy, Pharmaceutical Sciences School of Jinzhou Medical University, Jinzhou, China.
Research Department, Dalian Innovation Center of Laboratory Medicine Mass Spectrometry Technology, Dalian, China.
Front Endocrinol (Lausanne). 2022 Jun 1;13:897316. doi: 10.3389/fendo.2022.897316. eCollection 2022.
To investigate the relationship between plasma vitamin D2(VD2) and type 2 diabetes(T2DM).
Data from electronic medical records of 797 inpatients treated at Sun Yat Sen Memorial Hospital, Sun Yat-sen University between June 24, 2019 and December 24, 2020 were collected, and a total of 596 patients were enrolled after screening based on inclusion and exclusion criteria. Patients were divided into diabetic and non-diabetic groups according to whether they had T2DM. The Wilcoxon rank sum test was finally selected for the analysis of differences between groups according to the distribution of patients' plasma VD2, and logistic regression models were used to find the corresponding influencing factors.
Of the 596 hospitalized patients, 138 (23.15%) were diagnosed with T2DM. The Wilcoxon test showed no statistically significant difference in plasma VD2 concentrations between the T2DM and non-T2DM groups (p=0.833). After adjustment for confounders by multivariate logistic regression, there was still no significant difference in plasma VD2 concentrations between the two groups (P=0.316, OR: 1.15 (0.88,1.49)). The uncorrelated relationship between VD2 and T2DM was not found to change after incorporating 12 indicators, including demographic characteristics, laboratory indicators and complications, into the logistic regression model by 3 steps, even the OR (1.08 (0.92,1.26)) did not change in the 3 models. Similarly, the adjusted ORs agreed that there was no statistical association between VD2 and T2DM.
VD2 levels are similar in patients with T2DM compared to those without T2DM. Clinical caution should be exercised in giving VD2 supplementation to patients with T2DM unless other diseases requiring VD2 supplementation (e.g., rickets, osteoporosis) are present.
探讨血浆维生素 D2（VD2）与 2 型糖尿病（T2DM）的关系。
收集中山大学孙逸仙纪念医院 2019 年 6 月 24 日至 2020 年 12 月 24 日期间电子病历中的 797 例住院患者的数据，根据纳入和排除标准筛选后共纳入 596 例患者。根据患者是否患有 T2DM 将其分为糖尿病组和非糖尿病组。最终根据患者血浆 VD2 的分布情况，选择 Wilcoxon 秩和检验进行组间差异分析，采用 logistic 回归模型寻找相应的影响因素。
596 例住院患者中，138 例（23.15%）诊断为 T2DM。Wilcoxon 检验显示，T2DM 组和非 T2DM 组患者血浆 VD2 浓度无统计学差异（p=0.833）。多元 logistic 回归校正混杂因素后，两组血浆 VD2 浓度仍无统计学差异（P=0.316，OR：1.15（0.88，1.49））。通过逐步纳入包括人口统计学特征、实验室指标和并发症在内的 12 个指标，将 VD2 与 T2DM 之间的无相关性纳入 logistic 回归模型，结果并未改变。即使在 3 个模型中，OR（1.08（0.92，1.26））也没有变化。同样，调整后的 OR 也表明 VD2 与 T2DM 之间没有统计学关联。
与非 T2DM 患者相比，T2DM 患者的 VD2 水平相似。除非存在需要补充 VD2 的其他疾病（如佝偻病、骨质疏松症），否则在给予 T2DM 患者补充 VD2 时应谨慎。
