血浆游离氨基酸与中国 2 型糖尿病患者心血管疾病风险的关系。
Plasma Free Amino Acids and Risk of Cardiovascular Disease in Chinese Patients With Type 2 Diabetes.
机构信息
Department of Urology Surgery, Zhongshan Hospital of Dalian University, Dalian, China.
Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
出版信息
Front Endocrinol (Lausanne). 2021 Apr 14;11:519923. doi: 10.3389/fendo.2020.519923. eCollection 2020.
OBJECTIVES
This study aimed to explore associations between plasma free amino acids (PFAA) and risk of cardiovascular disease (CVD) in Chinese with Type 2 diabetes (T2D).
METHODS
We retrieved 741 inpatients with T2D consecutively from tertiary hospital. Twenty-three PFAA were measured. CVD was defined as having coronary heart disease (CHD) or stroke. Principal component analysis was used to extract factors of PFAA. Factors and their components were introduced into binary logistic regressions as continuous and tertiles to obtain OR (odds ratio) and 95% confidence interval (CI) for CVD (or its components) risk.
RESULTS
Of 741 inpatients, 282 (38.1%) had CVD (CHD alone: 122, stroke alone: 109, both: 51). Five factors were extracted, accounting for 65% of the total variance. Factor 3 composed of glutamate and tryptophan was associated with increased CVD risk (ORs, 95%CI of top vs. bottom tertiles: 1.60, 1.02-2.50 for CVD; 2.19, 1.17-4.07 for stroke, 1.51, 0.83-2.73 for CHD); the ORs (top vs. bottom tertiles) of glutamate were 2.62 (95%CI, 1.18-5.84) for stroke and 1.44 (0.80-2.61) for CHD; the ORs (top vs. bottom tertiles) of tryptophan were 1.50 (0.81-2.75) for stroke and 1.07 (0.58-1.97) for CHD. Comparable results were observed according to important confounders (all P for interaction >0.05).
CONCLUSIONS
Elevated factor 3 composed of glutamate and tryptophan was associated with increased CVD, especially stroke in T2D in China.
目的
本研究旨在探讨中国 2 型糖尿病（T2D）患者血浆游离氨基酸（PFAA）与心血管疾病（CVD）风险之间的关联。
方法
我们从三级医院连续检索了 741 名 T2D 住院患者。测量了 23 种 PFAA。CVD 定义为患有冠心病（CHD）或中风。采用主成分分析提取 PFAA 因子。将因子及其成分作为连续变量和三分位变量引入二项逻辑回归，以获得 CVD（或其成分）风险的比值比（OR）和 95%置信区间（CI）。
结果
741 名住院患者中，282 名（38.1%）患有 CVD（CHD 单独：122 例，中风单独：109 例，两者均有：51 例）。提取了 5 个因子，占总方差的 65%。由谷氨酸和色氨酸组成的因子 3 与 CVD 风险增加相关（ORs，顶端与低端三分位组的 95%CI：CVD：1.60，1.02-2.50；中风：2.19，1.17-4.07；CHD：1.51，0.83-2.73）；谷氨酸的 ORs（顶端与低端三分位组）为中风 2.62（95%CI，1.18-5.84）和 CHD 1.44（0.80-2.61）；色氨酸的 ORs（顶端与低端三分位组）为中风 1.50（81-2.75）和 CHD 1.07（0.58-1.97）。根据重要混杂因素（所有 P 交互>0.05）观察到类似的结果。
结论
由谷氨酸和色氨酸组成的升高的因子 3 与中国 T2D 患者 CVD 风险增加相关，尤其是中风。
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