Yu Luchao, Sun Yu, Wang Mingfei, Wu Yinghao, Zhang Xiaonong, Xu Jianguang
Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Orthopedic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ann Transl Med. 2022 May;10(10):537. doi: 10.21037/atm-22-2098.
Cervical fusion devices made by polyether ether ketone (PEEK) cause concomitant effects which decompress the spinal cord and nerve roots. Magnesium has good biocompatibility and bioactivity as a biodegradable orthopedic implant material; however, its fusion rate is low. In this paper, we aimed to improve interbody fusion rate of high-purity magnesium (HP-Mg) by coating it with fluoride.
Fluoride-coated HP-Mg (F-HP-Mg) cages were prepared, and HP-Mg cages served as controls. We tested hydrogen release in phosphate-buffered saline (PBS) and weight loss in chromic acid. Anterior cervical discectomy and bone graft fusion (ACDF) was performed at the C2-C3 segment on goats with F-HP-Mg and HP-Mg cages to evaluate fusion score.
Hydrogen release of F-HP-Mg cages was significantly lower than that of HP-Mg cages. Weight was significantly decreased in both types of cages after rinsing with chromic acid, while F-HP-Mg cages were more resistant to corrosion compared to HP-Mg cages. There were no significant differences in disc space height (DSH) and remaining cage volume between the two groups in computed tomography (CT) images of goat cervical spine, while cavities were found at postoperative 12 weeks and confirmed by histological staining. No complications were found, while serum aspartate aminotransaminase (AST) level was significantly higher in the HP-Mg group compared to the F-HP-Mg group. Fusion rate at 24 weeks after ACDF was significantly higher with F-HP-Mg cages.
The use of F-HP-Mg improved histological fusion in the cervical intervertebral space of goats compared to HP-Mg and showed good biosafety.
聚醚醚酮（PEEK）制成的颈椎融合器具有脊髓和神经根减压的伴随效应。镁作为一种可生物降解的骨科植入材料，具有良好的生物相容性和生物活性；然而，其融合率较低。在本文中，我们旨在通过用氟化物涂层来提高高纯度镁（HP-Mg）的椎间融合率。
制备了氟化物涂层的HP-Mg（F-HP-Mg）椎间融合器，并将HP-Mg椎间融合器作为对照。我们测试了在磷酸盐缓冲盐水（PBS）中的氢气释放以及在铬酸中的重量损失。在山羊的C2-C3节段使用F-HP-Mg和HP-Mg椎间融合器进行颈椎前路椎间盘切除及植骨融合术（ACDF），以评估融合评分。
F-HP-Mg椎间融合器的氢气释放明显低于HP-Mg椎间融合器。用铬酸冲洗后，两种类型的椎间融合器重量均显著降低，而F-HP-Mg椎间融合器比HP-Mg椎间融合器更耐腐蚀。山羊颈椎计算机断层扫描（CT）图像中，两组之间的椎间隙高度（DSH）和剩余椎间融合器体积没有显著差异，但在术后12周发现有空腔，并经组织学染色证实。未发现并发症，而HP-Mg组血清天冬氨酸转氨酶（AST）水平明显高于F-HP-Mg组。ACDF术后24周时，F-HP-Mg椎间融合器的融合率明显更高。
与HP-Mg相比，使用F-HP-Mg可改善山羊颈椎椎间的组织学融合，并显示出良好的生物安全性。
