Chen Guang, Zhang Xiaolong, Wang Qin, Qin Jie, Xu You-Zu, Li Xiang, Li Fei, Wang Xiang, Hu Bin, Chu Haiwei, Zheng Dexing, Zhang Jiecheng, Zhao Wenjun, Ma Lingping
Department of Vascular Surgery, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai, China.
Medical Research Center, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai, China.
Ann Transl Med. 2022 May;10(10):612. doi: 10.21037/atm-22-1542.
Floating right heart thrombi (FRHTS), known as thrombi in transit, are usually located in the atrium or ventricle. Generally, it occurs in patients with pulmonary embolism (PE) and dyspnea, chest pain, syncope and palpitations are the most common symptoms on presentation. The mortality of patients with FRHTS is higher than that of those without FRHTS. Current treatment includes anticoagulation, systemic thrombolysis, catheter directed interventions, and surgical embolectomy. However, there is no consensus on the optimal management options.
Herein, we report the case of a patient who presented with hypotension and tachycardia accompanied by an asymptomatic right leg deep vein thrombosis, right atrial thrombus, and pulmonary embolus. He had a history of radical resection of colon cancer 1 month prior. And he had developed chest tightness accompanied by stabbing pain in the chest area 1 day ago. He experienced an episode of syncope 8.5 hours ago. So he was referred to the local hospital. After the pulmonary computed tomography angiography (CTA) scan, he was diagnosed with pulmonary embolus and administrated with 5,000 u low molecular weight heparin. Then he was transferred to our hospital. On arrival in the emergency department, the bedside transthoracic echocardiography (TTE) revealed there was an enlarged right atrium and right ventricle, with a floating right atrial mass prolapsing through the tricuspid valve during diastole. The patient accepted anticoagulation treatment, but refused to undergo thrombolysis or surgical embolectomy. Eventually, the right heart thrombi (RiHT) floated to the left main branch of pulmonary artery. It was successfully treated by using AngioJet device and venoarterial extracorporeal membrane oxygenation (VA-ECMO). Our case provides clinical evidence supporting the feasibility and efficacy of AngioJet device and VA-ECMO in the treatment of the RiHT and PE.
Patients with PE combined with RiHT have higher mortality than those without RiHT, VA-ECMO could be used to maintain the circulation, and the AngioJet device could be used as an alternative treatment for patients who are reluctant to receive thrombolysis or surgical embolectomy.
漂浮性右心血栓(FRHTS),即移动性血栓,通常位于心房或心室。一般而言,它发生于肺栓塞(PE)患者,就诊时最常见的症状是呼吸困难、胸痛、晕厥和心悸。FRHTS患者的死亡率高于无FRHTS的患者。目前的治疗方法包括抗凝、全身溶栓、导管介入治疗和手术取栓。然而,对于最佳治疗方案尚无共识。
在此,我们报告一例患者,其表现为低血压和心动过速,伴有无症状的右下肢深静脉血栓形成、右心房血栓和肺栓塞。他1个月前有结肠癌根治切除术史。1天前出现胸闷并伴有胸部刺痛。8.5小时前发生一次晕厥。因此他被转诊至当地医院。经肺部计算机断层扫描血管造影(CTA)检查后,他被诊断为肺栓塞,并给予5000单位低分子肝素治疗。随后他被转至我院。到达急诊科时,床旁经胸超声心动图(TTE)显示右心房和右心室增大,舒张期有一个漂浮的右心房团块经三尖瓣脱垂。患者接受了抗凝治疗,但拒绝接受溶栓或手术取栓。最终,右心血栓(RiHT)漂浮至肺动脉左主支。使用AngioJet装置和静脉 - 动脉体外膜肺氧合(VA - ECMO)成功对其进行了治疗。我们的病例提供了临床证据,支持AngioJet装置和VA - ECMO治疗RiHT和PE的可行性和有效性。
PE合并RiHT的患者死亡率高于无RiHT的患者,VA - ECMO可用于维持循环,对于不愿接受溶栓或手术取栓的患者,AngioJet装置可作为替代治疗方法。