Barboza Trinita, Susta Leonardo, Reavill Drury, Beaufrère Hugues
University of Guelph, Guelph, ON, Canada.
Tufts University, North Grafton, MA.
Vet Pathol. 2023 Jan;60(1):133-138. doi: 10.1177/03009858221105058. Epub 2022 Jun 20.
Hepatic lipidosis is a common disease of captive bearded dragons (). Diagnosis, prevention, and treatment of this condition are challenging, as there is minimal information in the literature. Our study determined the prevalence and epidemiological risk factors associated with the grade and severity of hepatic lipid changes in bearded dragons submitted for necropsy in 2 North American institutions. A total of 571 postmortem cases were retrieved, and from each pathology report the demographic data (age, sex) and the list of final diagnoses were extracted. For each case diagnosed with hepatic lipidosis, the archived sections of liver were reviewed and the severity of lipid change was stratified using a standardized histologic grading system. Descriptive statistics were used to estimate the prevalence of each grade and severity class. Associations between grade and severity, as well as demographic data and concurrent diseases, were explored using ordinal logistic regression analysis. On multiple logistic models, the occurrence of infectious disease and neoplasia was associated with decreased grade and severity of hepatic lipid changes, while the female sex and adult age were associated with an increased grade and severity. None of the other variables were significantly associated with hepatic lipid changes. These results suggest that reproductively active females and adult bearded dragons are predisposed to increasing hepatic lipid changes, while those with an underlying disease process have reduced hepatic lipid accumulation and changes, possibly due to increased fat catabolism. Data in this study can serve to benchmark the prevalence of hepatic lipidosis in bearded dragons and allow further investigations.
肝脂沉积症是圈养鬃狮蜥常见的疾病。由于文献中相关信息极少，对这种病症的诊断、预防和治疗颇具挑战。我们的研究确定了在北美两家机构接受尸检的鬃狮蜥肝脏脂质变化的等级和严重程度相关的患病率及流行病学风险因素。共检索到571例尸检病例，并从每份病理报告中提取了人口统计学数据（年龄、性别）和最终诊断清单。对于每例诊断为肝脂沉积症的病例，复查存档的肝脏切片，并使用标准化组织学分级系统对脂质变化的严重程度进行分层。采用描述性统计来估计每个等级和严重程度类别的患病率。使用有序逻辑回归分析探讨等级和严重程度之间以及人口统计学数据和并发疾病之间的关联。在多个逻辑模型中，传染病和肿瘤的发生与肝脏脂质变化的等级和严重程度降低有关，而雌性和成年与等级和严重程度增加有关。其他变量均与肝脏脂质变化无显著关联。这些结果表明，生殖活跃的雌性和成年鬃狮蜥易发生肝脏脂质变化增加，而患有潜在疾病的鬃狮蜥肝脏脂质积累和变化减少，这可能是由于脂肪分解代谢增加所致。本研究中的数据可用于确定鬃狮蜥肝脂沉积症的患病率，并为进一步研究提供依据。
