Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Department of Dermatology, Toranomon Hospital, Tokyo, Japan.
Microb Drug Resist. 2022 Aug;28(8):861-866. doi: 10.1089/mdr.2021.0319. Epub 2022 Jun 20.
, a major skin bacterium, can cause opportunistic infections. Use of antimicrobial agents against for acne treatment becomes a risk factor for emergence of antimicrobial-resistant skin bacteria. In this study, the impact of antimicrobial treatment of acne vulgaris on antimicrobial resistance was assessed. A total of 344 strains isolated from patients with acne vulgaris who visited hospital (165 strains) and dermatological clinics (179 strains), respectively, were analyzed. Except for doxycycline, the resistance rates were higher in strains isolated from patients who had used antimicrobials for acne treatment than in those isolated from patients who had not used antimicrobials. The prevalence rates of strains with (C) from patients who used macrolides and clindamycin (hospital, 78.0%; clinics, 61.3%) and those of strains with (M) from patients who used tetracyclines (hospital, 27.5%; clinics, 42.4%) were significantly higher than those of strains from patients who did not use antimicrobials ( < 0.05). All strains with (A) (8/8) and 91.7% strains with (C) (156/170) showed high-level resistance to macrolides and clindamycin (MIC ≥256 μg/mL). Furthermore, almost all strains with (M) showed resistance to minocycline. Our results showed that the use of antimicrobials for acne treatment may lead to an increased prevalence of antimicrobial-resistant . In particular, the emergence of minocycline-resistant strains with (M) owing to the use of tetracyclines (doxycycline and minocycline) is a critical issue. Appropriate antimicrobial use for acne treatment may be an important strategy to prevent the emergence of antimicrobial-resistant skin bacteria.
痤疮丙酸杆菌是一种主要的皮肤细菌，可引起机会性感染。将抗菌药物用于治疗痤疮会增加出现抗菌药物耐药的皮肤细菌的风险。在这项研究中，评估了治疗寻常痤疮的抗菌药物对痤疮丙酸杆菌抗菌耐药性的影响。共分析了 344 株从分别就诊于医院（165 株）和皮肤科诊所（179 株）的寻常痤疮患者中分离出的菌株。除了多西环素外，与未使用抗菌药物治疗痤疮的患者相比，使用抗菌药物治疗痤疮的患者分离出的菌株的耐药率更高。使用大环内酯类和克林霉素的患者（医院 78.0%；诊所 61.3%）分离出的菌株中（C）型和使用四环素的患者（医院 27.5%；诊所 42.4%）分离出的菌株中（M）型的流行率明显高于未使用抗菌药物的患者（ < 0.05）。所有（A）型菌株（8/8）和 91.7%（C）型菌株（156/170）对大环内酯类和克林霉素呈高水平耐药（MIC ≥256 μg/mL）。此外，几乎所有（M）型菌株均对米诺环素耐药。我们的研究结果表明，治疗痤疮使用抗菌药物可能会导致抗菌药物耐药的痤疮丙酸杆菌流行率增加。特别是由于使用四环素（多西环素和米诺环素）而出现的（M）型米诺环素耐药菌株的出现是一个关键问题。适当使用抗菌药物治疗痤疮可能是预防抗菌药物耐药皮肤细菌出现的重要策略。
