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精神分裂症多基因风险与快速眼动睡眠纺锤体密度的关联取决于促进认知的变异体。

Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants.

机构信息

Central Institute of Mental Health, Sleep Laboratory, Medical Faculty Mannheim, Heidelberg University, J5, 68159, Mannheim, Germany.

Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1193-1203. doi: 10.1007/s00406-022-01435-3. Epub 2022 Jun 20.

DOI:10.1007/s00406-022-01435-3
PMID:35723738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9508216/
Abstract

Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles may represent such a biomarker as they are strongly genetically determined, associated with cognitive functioning and impaired in schizophrenia and unaffected relatives. We measured fast sleep spindle density in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS). The association between SCZ-PGS and fast spindle density was further characterized by stratifying it to the genetic background of intelligence. SCZ-PGS was positively associated with fast spindle density. This association mainly depended on pro-cognitive genetic variants. Our results strengthen the evidence for a genetic background of spindle abnormalities in schizophrenia. Spindle density might represent an easily accessible marker for a favourable cognitive outcome which should be further investigated in clinical samples.

摘要

认知障碍是精神分裂症的一个常见特征，也是长期预后的最强预测因素。确定与精神分裂症认知结果相关的遗传背景特征，可能有助于更深入地了解临床疾病亚型。快速睡眠纺锤波可能就是这样的生物标志物，因为它们具有很强的遗传决定因素，与认知功能有关，在精神分裂症患者及其未受影响的亲属中受到损害。我们测量了 150 名健康成年人的快速睡眠纺锤波密度，并研究了其与精神分裂症全基因组多基因评分（SCZ-PGS）之间的关联。通过将其分层到智力的遗传背景，进一步描述了 SCZ-PGS 与快速纺锤波密度之间的关联。SCZ-PGS 与快速纺锤波密度呈正相关。这种关联主要取决于促进认知的遗传变异。我们的研究结果进一步证实了精神分裂症中纺锤体异常的遗传背景。纺锤波密度可能代表着一种容易获得的有利认知结果的标志物，应在临床样本中进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f783/9508216/6921902439ea/406_2022_1435_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f783/9508216/bdc677244f82/406_2022_1435_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f783/9508216/6921902439ea/406_2022_1435_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f783/9508216/bdc677244f82/406_2022_1435_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f783/9508216/6921902439ea/406_2022_1435_Fig2_HTML.jpg

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1
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Psychiatry Res. 2022 Jan;307:114265. doi: 10.1016/j.psychres.2021.114265. Epub 2021 Nov 13.
2
Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults.与精神分裂症相关的 ZNF804A 变异与健康年轻成年人睡眠慢波和纺锤波的经验依赖性动力学改变有关。
Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab191.
3
Systematic review: the relationship between sleep spindle activity with cognitive functions, positive and negative symptoms in psychosis.
系统评价：睡眠纺锤波活动与精神病患者认知功能、阳性和阴性症状之间的关系。
Sleep Med X. 2020 Aug 29;2:100025. doi: 10.1016/j.sleepx.2020.100025. eCollection 2020 Dec.
4
Genetic architecture of schizophrenia: a review of major advancements.精神分裂症的遗传结构：主要进展综述
Psychol Med. 2021 Oct;51(13):2168-2177. doi: 10.1017/S0033291720005334. Epub 2021 Feb 8.
5
Sleep, sleep spindles, and cognitive functions in drug-naive patients with first-episode psychosis.睡眠、睡眠纺锤波与首发精神病患者认知功能的关系。
J Clin Sleep Med. 2020 Dec 15;16(12):2079-2087. doi: 10.5664/jcsm.8776.
6
Polygenic risk scores: from research tools to clinical instruments.多基因风险评分：从研究工具到临床工具。
Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5.
7
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits.CACNA1I 基因中的新生致病变异体小鼠模型揭示精神分裂症风险基因与睡眠纺锤波减少的关联
Transl Psychiatry. 2020 Jan 23;10(1):29. doi: 10.1038/s41398-020-0685-1.
8
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9
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