Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Ophthalmology, The Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Retina. 2022 Jul 1;42(7):1356-1363. doi: 10.1097/IAE.0000000000003444.
To study the utility of MultiColor confocal scanning laser ophthalmoscope imaging (MCI) in identifying the morphology of uveitic lesions compared with conventional color fundus photography (CFP) in patients with posterior uveitis.
In this prospective observational study, subjects with posterior uveitis underwent MCI and CFP. The images obtained by the two modalities were analyzed by two independent reviewers for vitreoretinal surface abnormalities, retinal fluid and hemorrhages, and depth/location of lesions. These findings were compared with the clinical findings and other imaging techniques.
Sixty-nine eyes of 43 patients (25 men) with mean age of 33.5 ± 13.9 years were studied. MultiColor imaging had better sensitivity and specificity in detecting vitreoretinal interface abnormalities, such as epiretinal membrane and inner retinal striae, compared with CFP. MultiColor imaging failed to detect retinochoroiditis lesions in 5 of 6 eyes (83%) and choroiditis in 9 46 eyes (20%), which were detected on CFP and clinical examination. Also, MCI showed a high false-positive rate of 34% in detecting intraretinal hemorrhages.
Retinochoroidal lesions in posterior uveitis may be poorly identified on MCI compared with CFP and clinical examination. One must exercise caution in commenting on disease morphology based on MCI alone.
研究多色共焦扫描激光检眼镜成像（MCI）在识别后葡萄膜炎患者葡萄膜病变形态方面的效用，与传统眼底彩色照相术（CFP）相比。
在这项前瞻性观察研究中，后葡萄膜炎患者接受 MCI 和 CFP 检查。两名独立的审查员对两种方式获得的图像进行分析，用于评估视网膜表面异常、视网膜液体积聚和出血，以及病变的深度/位置。这些发现与临床发现和其他成像技术进行了比较。
43 名患者（25 名男性）的 69 只眼，平均年龄为 33.5 ± 13.9 岁。与 CFP 相比，MCI 检测视网膜玻璃体界面异常（如视网膜前膜和内视网膜条纹）的敏感性和特异性更好。MCI 未能在 6 只眼中（83%）检测到视网膜脉络膜炎病变，在 9 只眼中（20%）检测到脉络膜炎病变，这些病变在 CFP 和临床检查中都可以发现。此外，MCI 在检测视网膜内出血方面的假阳性率高达 34%。
与 CFP 和临床检查相比，MCI 在后葡萄膜炎中的视网膜脉络膜病变可能识别较差。基于 MCI 本身，必须谨慎评论疾病形态。
