Paiement G, Wessinger S J, Waltman A C, Harris W H
J Arthroplasty. 1987;2(1):23-6. doi: 10.1016/s0883-5403(87)80027-x.
Lower doses of warfarin are effective in the treatment of proven proximal deep vein thrombosis (DVT), and at a substantially lower risk of bleeding complications than with standard doses. The authors compared low-dose warfarin with external pneumatic compression (EPC) boots for prophylaxis against DVT and efficacy and safety in a population of total hip replacement patients at high risk for DVT and bleeding complications. DVT developed in 12 of 72 patients on low-dose warfarin and 11 of 66 patients on EPC. Both regimens were as efficacious as traditional higher doses of warfarin used in prior studies. No major bleeding complications occurred in either group. Low-dose warfarin appears to be an effective and relatively safe form of prophylaxis against postoperative DVT, as does sequential EPC of the calf and thigh.
低剂量华法林在治疗已确诊的近端深静脉血栓形成（DVT）方面有效，且与标准剂量相比，出血并发症风险显著更低。作者比较了低剂量华法林与外部气动压迫（EPC）靴在预防全髋关节置换术患者DVT方面的效果及安全性，这些患者发生DVT和出血并发症的风险较高。接受低剂量华法林治疗的72例患者中有12例发生DVT，接受EPC治疗的66例患者中有11例发生DVT。两种治疗方案都与先前研究中使用的传统较高剂量华法林一样有效。两组均未发生严重出血并发症。低剂量华法林似乎是预防术后DVT的一种有效且相对安全的方法，小腿和大腿的序贯EPC也是如此。
