Mollnes T E, Vandvik B, Lea T, Vartdal F
J Neurol Sci. 1987 Mar;78(1):17-28. doi: 10.1016/0022-510x(87)90074-8.
The terminal complement complex (TCC) was determined in plasma and cerebrospinal fluid (CSF) from 208 neurological patients. Elevated CSF TCC levels were observed in higher frequencies in patients with infectious diseases (80%), radiculoneuritis (62%), multiple sclerosis (30%), and miscellaneous autoimmune diseases (27%) than in patients with miscellaneous non-inflammatory diseases (2-13%). The plasma level of TCC was significantly increased only in the infectious group. No positive correlation was observed between the plasma and the CSF TCC concentration in the whole patient population nor in subgroups divided according to blood-brain barrier function. Furthermore, the CSF TCC concentration did not correlate with the serum/CSF albumin ratio or with CSF total protein concentration when this was below 1.0 g/l. It is concluded that an elevated TCC concentration in CSF reflects intrathecal complement activation and that quantification of TCC in CSF may be a valuable supplement in the examination of neurological diseases.
在208例神经系统疾病患者的血浆和脑脊液（CSF）中测定了终末补体复合物（TCC）。与患有各种非炎症性疾病（2%-13%）的患者相比，感染性疾病（80%）、神经根神经炎（62%）、多发性硬化症（30%）和各种自身免疫性疾病（27%）患者的脑脊液TCC水平升高频率更高。仅感染组的TCC血浆水平显著升高。在整个患者群体中以及根据血脑屏障功能划分的亚组中，血浆和脑脊液TCC浓度之间均未观察到正相关。此外，当脑脊液总蛋白浓度低于1.0 g/l时，脑脊液TCC浓度与血清/脑脊液白蛋白比值或脑脊液总蛋白浓度均无相关性。得出的结论是，脑脊液中TCC浓度升高反映鞘内补体激活，脑脊液中TCC的定量可能是神经系统疾病检查中有价值的补充。
