Statins are widely accepted hypolipidemics that work by inhibiting hydroxymethylglutaryl coenzyme A reductase and thereby inhibiting cholesterol synthesis. They significantly reduce cardiovascular risk. Their use could be associated with side effects, which are serious only in rare cases. However, an unhealthy lifestyle, obesity, and elevation of blood lipids do not only damage the cardiovascular system. The current topic not only in hepatology is non-alcoholic fatty liver disease - NAFLD. The aim of this article is, among others, to draw attention to the pleiotropic effects of statins, which could be used in the treatment of this disease in the future. Recent studies have suggested that the administration of statins to patients with NAFLD is beneficial.
他汀类药物是广泛接受的降脂药物，通过抑制羟甲基戊二酰辅酶 A 还原酶从而抑制胆固醇合成。它们显著降低心血管风险。他汀类药物的使用可能与副作用相关，但这些副作用仅在极少数情况下较为严重。然而，不健康的生活方式、肥胖和血脂升高不仅会损害心血管系统。目前，非酒精性脂肪性肝病（NAFLD）不仅是肝病学的热门话题。本文的目的除其他外，还在于提请人们注意他汀类药物的多效性作用，这些作用将来可能会被用于治疗这种疾病。最近的研究表明，对 NAFLD 患者给予他汀类药物治疗是有益的。
