The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
China Medical University, Shenyang, China.
BMC Psychiatry. 2022 Jun 21;22(1):415. doi: 10.1186/s12888-022-04038-3.
We design a diagnostic test to evaluate the effectiveness and accuracy of A non-intrusive Wearable Diagnostic Assessment System versus SNAP-IV for auxiliary diagnosis of children with ADHD.
This study included 55 children aged 6-16 years who were clinically diagnosed with ADHD by DSM-5, and 55 healthy children (typically developing). Each subject completes 10 tasks on the WeDA system (Wearable Diagnostic Assessment System) and Parents of each subject complete the SNAP-IV scale. We will calculate the validity indexes, including sensitivity, specificity, Youden's index, likelihood ratio, and other indexes including predictive value, diagnostic odds ratio, diagnostic accuracy and area under the curve [AUC] to assess the effectiveness of the WeDA system as well as the SNAP-IV.
The sensitivity (94.55% vs. 76.36%) and the specificity (98.18% vs. 80.36%) of the WeDA system were significantly higher than the SNAP-IV. The AUC of the WeDA system (0.964) was higher than the SNAP-IV (0.907). There is non-statistically significant difference between groups (p = 0.068), and both of them have high diagnostic accuracy. In addition, the diagnostic efficacy of the WeDA system was higher than that of SNAP-IV in terms of the Youden index, diagnostic accuracy, likelihood ratio, diagnostic odds ratio and predictive value.
The advantages of the WeDA system in terms of diagnostic objectivity, scientific design and ease of operation make it a promising system for widespread use in clinical practice.
我们设计了一项诊断测试,以评估非侵入式可穿戴诊断评估系统(WeDA 系统)对辅助诊断 ADHD 儿童的有效性和准确性,与 SNAP-IV 进行对比。
本研究纳入了 55 名年龄在 6-16 岁之间、经 DSM-5 临床诊断为 ADHD 的儿童,以及 55 名健康儿童(正常发育)。每位受试者完成 10 项 WeDA 系统(可穿戴诊断评估系统)任务,每位受试者的家长完成 SNAP-IV 量表。我们将计算有效性指标,包括敏感性、特异性、Youden 指数、似然比以及包括预测值、诊断比值比、诊断准确性和曲线下面积(AUC)在内的其他指标,以评估 WeDA 系统和 SNAP-IV 的有效性。
WeDA 系统的敏感性(94.55% 比 76.36%)和特异性(98.18% 比 80.36%)均显著高于 SNAP-IV。WeDA 系统的 AUC(0.964)高于 SNAP-IV(0.907)。两组间无统计学差异(p=0.068),且均具有较高的诊断准确性。此外,在 Youden 指数、诊断准确性、似然比、诊断比值比和预测值方面,WeDA 系统的诊断效果均优于 SNAP-IV。
WeDA 系统在诊断客观性、科学设计和操作简便性方面具有优势,有望在临床实践中广泛应用。