Ünal A, Baykal O, Öztürk N
Faculty of Medicine, Department of Ophthalmology, Artvin State Hospital, Atatürk University, Çarşı District, Hospital Street, No:5, 08000, Artvin, Turkey.
Faculty of Medicine, Department of Ophthalmology, Ataturk University, Erzurum, Turkey.
Int J Retina Vitreous. 2022 Jun 21;8(1):44. doi: 10.1186/s40942-022-00394-0.
MMP-9 plays a prominent role in inflammation and MMP-14 take part in angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between diabetic and non-diabetic patients.
The patients who scheduled for pars plana vitrectomy were included in our study. Patients are divided into 2 groups: the diabetic group and non-diabetic group. Age, gender, intraocular pressure(IOP), visual acuity (VA) were reported. Color fundus photography, fundus fluorescein angiography, optic coherence tomography (OCT) were performed before and after the operation. MMP-9 and MMP-14 levels in vitreous samples were analyzed with a reader device by ELISA method. Mann-Whitney U test and logistic regressions were used in statistical analysis, p < 0.05 accepted as statistically significant.
70 eyes of 70 patients who received pars plana vitrectomy were enrolled in the study and divided into 2 groups: 34 patients in the diabetic group, 36 patients in the non-diabetic group. The average age of diabetic patients was 60.14 ± 10.20, and non-diabetic patients was 64.22 ± 11.16, respectively. The average MMP-9 (0.67 ± 0.66 ng/ml) and MMP-14 (0.16 ± 0.45 ng/ml) values in the diabetic group were significantly higher than the average MMP-9 (0.21 ± 0.05 ng/ml) and MMP-14 (and 0.07 ± 0.02 ng/ml) values in the non-diabetic group (P < 0.01). Also, it was observed that MMP-9 and MMP-14 levels increases as the diabetic disease duration increases. The risk of diabetes incidence increased with high levels of MMP-9 and MMP-14.
Due to the higher levels of MMP-9 and MMP-14 in the pathogenesis of diabetic retinopathy, these proteins may probably be among the therapeutic targets in the prevention and treatment of retinopathy.
基质金属蛋白酶-9（MMP-9）在炎症中起重要作用，基质金属蛋白酶-14（MMP-14）参与血管生成。本研究的目的是比较糖尿病患者和非糖尿病患者的MMP-9和MMP-14水平。
将计划行玻璃体切除术的患者纳入本研究。患者分为两组：糖尿病组和非糖尿病组。记录年龄、性别、眼压（IOP）、视力（VA）。术前和术后进行彩色眼底照相、眼底荧光血管造影、光学相干断层扫描（OCT）。采用酶联免疫吸附测定（ELISA）法，使用读数装置分析玻璃体样本中的MMP-9和MMP-14水平。统计分析采用曼-惠特尼U检验和逻辑回归，P < 0.05被认为具有统计学意义。
70例行玻璃体切除术患者的70只眼纳入研究，分为两组：糖尿病组34例，非糖尿病组36例。糖尿病患者的平均年龄为60.14 ± 10.20岁，非糖尿病患者的平均年龄为64.22 ± 11.16岁。糖尿病组的平均MMP-9（0.67 ± 0.66 ng/ml）和MMP-14（0.16 ± 0.45 ng/ml）值显著高于非糖尿病组的平均MMP-9（0.21 ± 0.05 ng/ml）和MMP-14（0.07 ± 0.02 ng/ml）值（P < 0.01）。此外，观察到MMP-9和MMP-14水平随着糖尿病病程的增加而升高。糖尿病发病风险随着MMP-9和MMP-14水平升高而增加。
由于糖尿病视网膜病变发病机制中MMP-9和MMP-14水平较高，这些蛋白可能是视网膜病变防治的治疗靶点之一。
