• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

幼年时期持续光照会导致鸡出现与恐惧相关的行为，同时伴有褪黑素分泌受抑制以及海马体中与生物钟和脑源性神经营养因子相关基因的表达紊乱。

Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes.

作者信息

Yang Yang, Cong Wei, Liu Jie, Zhao Mindie, Xu Peirong, Han Wanwan, Wang Deyun, Zhao Ruqian

机构信息

MOE Joint International Research Laboratory of Animal Health & Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

出版信息

J Anim Sci Biotechnol. 2022 Jun 21;13(1):67. doi: 10.1186/s40104-022-00720-4.

DOI:10.1186/s40104-022-00720-4
PMID:35729672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9215013/
Abstract

BACKGROUND

Light management plays an important role in the growth and behavior of broiler chickens. Constant light in early post hatch stage has been a common practice in broiler industry for improving growth performance, while whether and how constant light in early life affects the behavior of broiler chickens is rarely reported.

RESULTS

In this study, newly hatched chicks were kept in either constant (24 L:0 D, LL) or (12 L:12 D, LD) photoperiod for 7 d and then maintained in 12 L:12 D thereafter until 21 days of age. Constant light increased the average daily feed intake but not the body weight, which led to higher feed conversion ratio. Chickens in LL group exhibited fear-related behaviors, which was associated with higher corticosterone, lower melatonin and 5-HT levels. Concurrently, constant light exposure increased the mRNA expression of clock-related genes and suppressed the expression of antioxidative genes in the hippocampus. Moreover, brain derived neurotrophic factor/extracellular signal-regulated kinase (BDNF/ERK) pathway was suppressed in the hippocampus of chickens exposed to constant light in the first week post hatching.

CONCLUSIONS

These findings indicate that constant light exposure in early life suppress melatonin secretion and disrupts hippocampal expression of genes involved in circadian clock and BDNF/ERK pathway, thereby contributing to fear-related behaviors in the chicken.

摘要

背景

光照管理在肉鸡的生长和行为中起着重要作用。孵化后早期阶段持续光照是肉鸡行业提高生长性能的常见做法，然而早期持续光照是否以及如何影响肉鸡行为的报道却很少。

结果

在本研究中，刚孵出的雏鸡在持续（24小时光照：0小时黑暗，LL）或（12小时光照：12小时黑暗，LD）光周期下饲养7天，之后维持在12小时光照：12小时黑暗直至21日龄。持续光照增加了平均日采食量，但未增加体重，这导致了更高的饲料转化率。LL组的鸡表现出与恐惧相关的行为，这与较高的皮质酮、较低的褪黑素和5-羟色胺水平有关。同时，持续光照增加了时钟相关基因的mRNA表达，并抑制了海马体中抗氧化基因的表达。此外，在孵化后第一周暴露于持续光照的鸡的海马体中，脑源性神经营养因子/细胞外信号调节激酶（BDNF/ERK）通路受到抑制。

结论

这些发现表明，早期持续光照会抑制褪黑素分泌，破坏海马体中参与昼夜节律时钟和BDNF/ERK通路的基因表达，从而导致鸡出现与恐惧相关的行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/b137433b3df7/40104_2022_720_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/08ff6037d594/40104_2022_720_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/553a99ee2572/40104_2022_720_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/ec456b8703fe/40104_2022_720_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/bff2a269d907/40104_2022_720_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/b137433b3df7/40104_2022_720_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/08ff6037d594/40104_2022_720_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/553a99ee2572/40104_2022_720_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/ec456b8703fe/40104_2022_720_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/bff2a269d907/40104_2022_720_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8151/9215013/b137433b3df7/40104_2022_720_Fig5_HTML.jpg

相似文献

1
Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes.幼年时期持续光照会导致鸡出现与恐惧相关的行为，同时伴有褪黑素分泌受抑制以及海马体中与生物钟和脑源性神经营养因子相关基因的表达紊乱。
J Anim Sci Biotechnol. 2022 Jun 21;13(1):67. doi: 10.1186/s40104-022-00720-4.
2
Constant light exposure in early life induces m6A-mediated inhibition of IGF gene family in the chicken.早期持续光照会诱导鸡的 IGF 基因家族中 m6A 介导的抑制。
J Anim Sci. 2022 Jul 1;100(7). doi: 10.1093/jas/skac199.
3
Pineal oscillator functioning in the chicken--effect of photoperiod and melatonin.松果腺振荡器在鸡中的作用——光周期和褪黑素的影响。
Chronobiol Int. 2014 Feb;31(1):134-43. doi: 10.3109/07420528.2013.832279. Epub 2013 Oct 17.
4
Daily rhythms of clock gene expression and feeding behavior during the larval development in gilthead seabream, Sparus aurata.金头鲷（Sparus aurata）幼体发育过程中生物钟基因表达和摄食行为的每日节律。
Chronobiol Int. 2015;32(8):1061-74. doi: 10.3109/07420528.2015.1058271. Epub 2015 Aug 28.
5
Photoperiodic lighting (16 hours of light:8 hours of dark) programs during incubation: 1. Effects on growth and circadian physiological traits of embryos and early stress response of broiler chickens.孵化期间的光周期照明（16 小时光照：8 小时黑暗）方案：1. 对胚胎生长和昼夜生理特征以及肉鸡早期应激反应的影响。
Poult Sci. 2012 Nov;91(11):2912-21. doi: 10.3382/ps.2012-02426.
6
Effect of night light regimen on growth performance, antioxidant status and health of broiler chickens from 1 to 21 days of age.夜间光照方案对1至21日龄肉鸡生长性能、抗氧化状态及健康状况的影响。
Asian-Australas J Anim Sci. 2019 Jun;32(6):904-911. doi: 10.5713/ajas.18.0525. Epub 2018 Oct 26.
7
Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring.孕期生物钟紊乱会损害成年子代海马体中N-甲基-D-天冬氨酸受体亚基Grin1b/Grin3a的表达以及空间记忆。
PLoS One. 2014 Mar 24;9(3):e91313. doi: 10.1371/journal.pone.0091313. eCollection 2014.
8
Effects of early nutrition and transport of 1-day-old chickens on production performance and fear response.1 日龄雏鸡早期营养和运输对生产性能和恐惧反应的影响。
Poult Sci. 2018 Jul 1;97(7):2534-2542. doi: 10.3382/ps/pey106.
9
Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland.鸡松果体中血清素昼夜节律的季节性胚后成熟。
Chronobiol Int. 2015 Feb;32(1):59-70. doi: 10.3109/07420528.2014.955185. Epub 2014 Sep 15.
10
Providing colored photoperiodic light stimulation during incubation: 2. Effects on early posthatch growth, immune response, and production performance in broiler chickens.孵化期间提供彩色光周期刺激：2. 对肉鸡早期出壳后生长、免疫反应和生产性能的影响。
Poult Sci. 2021 Sep;100(9):101328. doi: 10.1016/j.psj.2021.101328. Epub 2021 Jun 12.

引用本文的文献

1
Effects of different photoperiods on melatonin level, cecal microbiota and breast muscle morphology of broiler chickens.不同光周期对肉鸡褪黑素水平、盲肠微生物群及胸肌形态的影响。
Front Microbiol. 2025 Mar 25;16:1504264. doi: 10.3389/fmicb.2025.1504264. eCollection 2025.
2
Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys.抗生素/抗球虫药暴露可诱导肠道-脑轴重塑，以激活感染禽致病性大肠杆菌的火鸡体内的Akt/mTOR并实现脑源性神经营养因子介导的神经保护作用。
Poult Sci. 2025 Feb;104(2):104636. doi: 10.1016/j.psj.2024.104636. Epub 2024 Dec 4.
3

本文引用的文献

1
Chronic corticosterone disrupts the circadian rhythm of CRH expression and mA RNA methylation in the chicken hypothalamus.慢性皮质酮会破坏鸡下丘脑促肾上腺皮质激素释放激素（CRH）表达的昼夜节律以及mRNA甲基化。
J Anim Sci Biotechnol. 2022 Mar 8;13(1):29. doi: 10.1186/s40104-022-00677-4.
2
Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression.褪黑素、神经炎症与抑郁症脑改变的相关性。
Int J Mol Sci. 2021 Dec 28;23(1):305. doi: 10.3390/ijms23010305.
3
Melatonin alleviates hippocampal GR inhibition and depression-like behavior induced by constant light exposure in mice.
Photostimulation decreases fearfulness, but improves growth performance and egg quality of breeder Pekin ducks.
光刺激可降低种用北京鸭的恐惧情绪，但能提高其生长性能和蛋品质。
Poult Sci. 2025 Jan;104(1):104563. doi: 10.1016/j.psj.2024.104563. Epub 2024 Nov 22.
4
Characterisation of runs of homozygosity and inbreeding coefficients in the red-brown Korean native chickens.红棕色韩国本土鸡纯合子片段及近亲繁殖系数的特征分析
Anim Biosci. 2024 Aug;37(8):1355-1366. doi: 10.5713/ab.23.0514. Epub 2024 Apr 25.
5
Circadian Corticosterone Profile in Laying Hens ().蛋鸡的昼夜皮质酮谱（）。
Animals (Basel). 2024 Mar 12;14(6):873. doi: 10.3390/ani14060873.
6
Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System.短光周期对易患僵住症的不同小鼠行为和脑可塑性的影响：脑源性神经营养因子和血清素系统的作用
Int J Mol Sci. 2024 Feb 20;25(5):2469. doi: 10.3390/ijms25052469.
7
Measuring Chronic Stress in Broiler Chickens: Effects of Environmental Complexity and Stocking Density on Immunoglobulin-A Levels.测量肉鸡的慢性应激：环境复杂性和饲养密度对免疫球蛋白A水平的影响。
Animals (Basel). 2023 Jun 22;13(13):2058. doi: 10.3390/ani13132058.
8
LED Light Applied to the Feeder: Impact on Growth Performances of Chickens under Productive Conditions.应用于喂料器的LED灯：对生产条件下鸡生长性能的影响
Vet Sci. 2023 Apr 21;10(4):306. doi: 10.3390/vetsci10040306.
9
Constant light exposure in early life induces m6A-mediated inhibition of IGF gene family in the chicken.早期持续光照会诱导鸡的 IGF 基因家族中 m6A 介导的抑制。
J Anim Sci. 2022 Jul 1;100(7). doi: 10.1093/jas/skac199.
褪黑素可减轻持续光照诱导的小鼠海马GR抑制及抑郁样行为。
Ecotoxicol Environ Saf. 2021 Nov 15;228:112979. doi: 10.1016/j.ecoenv.2021.112979.
4
Neural representations of space in the hippocampus of a food-caching bird.食籽鸟海马体中空间的神经表象。
Science. 2021 Jul 16;373(6552):343-348. doi: 10.1126/science.abg2009.
5
Exposure to constant light impairs cognition with FTO inhibition and mA-dependent TrκB repression in mouse hippocampus.持续光照会通过 FTO 抑制和 mA 依赖性 TrkB 抑制损害小鼠海马体认知功能。
Environ Pollut. 2021 Aug 15;283:117037. doi: 10.1016/j.envpol.2021.117037. Epub 2021 Mar 30.
6
Functional/physicochemical properties and oxidative stability of ground meat from broilers reared under different photoperiods.不同光周期下饲养肉鸡的绞碎肉的功能/物理化学特性和氧化稳定性。
Poult Sci. 2020 Jul;99(7):3761-3768. doi: 10.1016/j.psj.2020.04.021. Epub 2020 May 6.
7
Keel bone fractures induce a depressive-like state in laying hens.龙骨骨折会导致产蛋母鸡出现类似抑郁的状态。
Sci Rep. 2020 Feb 20;10(1):3007. doi: 10.1038/s41598-020-59940-1.
8
Circadian disruption and divergent microbiota acquisition under extended photoperiod regimens in chicken.延长光照周期方案下鸡的昼夜节律紊乱与微生物群获取差异
PeerJ. 2019 Mar 14;7:e6592. doi: 10.7717/peerj.6592. eCollection 2019.
9
Differential and temporal expression of corticotropin releasing hormone and its receptors in the nucleus of the hippocampal commissure and paraventricular nucleus during the stress response in chickens (Gallus gallus).在应激反应中鸡（Gallus gallus）的海马连合核和室旁核中促肾上腺皮质释放激素及其受体的差异和时程表达。
Brain Res. 2019 Jul 1;1714:1-7. doi: 10.1016/j.brainres.2019.02.018. Epub 2019 Feb 14.
10
Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways.持续光照会加速免疫衰老样状态，而褪黑素或姜黄素通过 DJ-1/Nrf2 和 P53/Bax 通路给药可以对抗这种状态。
J Photochem Photobiol B. 2018 Sep;186:69-80. doi: 10.1016/j.jphotobiol.2018.07.003. Epub 2018 Jul 9.