Department of Internal Medicine, Hisar Intercontinental Hospital, İstanbul, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Jun;26(11):3989-3994. doi: 10.26355/eurrev_202206_28969.
Insulin resistance is an important risk factor for developing metabolic syndromes that cause morbidity diseases such as diabetes and cardiovascular diseases. Interestingly, in chronic inflammatory diseases, some inflammatory mediators can play, either directly or indirectly, a pivot role in the development of insulin resistance. This can be considered as an additional factor causing increased mortality and morbidity in these patients. In this paper, we want to investigate and compare the insulin resistance status in patients with Inflammatory Bowel Disease (IBD) and healthy control, as well as different stages of patients with Ulcerative colitis (UC) and Crohn's Disease (CD).
A total of 180 patients were enrolled in this study; while 95 patients had inflammatory bowel disease [Crohn's Disease (n): 47, Ulcerative colitis (n): 48], 85 people were healthy controls. Insulin resistance status was evaluated with the HOMA-IR (hemostasis model of assessment of insulin resistance) index. p < 0.05 was accepted as significant.
The mean HOMA-IR levels were found to be similar for both IBD and control, and Crohn's disease and control (p = 0.174, p = 0.96, respectively); but the mean HOMA-IR score in ulcerative colitis, one of the IBD subgroups, was significantly higher than the control group (p < 0.039).
This study clearly showed that insulin resistance is increased in ulcerative colitis. Consequently, patients with ulcerative colitis should be followed and closely monitored for developing insulin resistance, metabolic syndromes, diabetes, and cardiovascular diseases. Consequently, all of them can cause an additional risk of morbidity and mortality in these patients.
胰岛素抵抗是导致代谢综合征的重要危险因素，而代谢综合征会导致糖尿病和心血管疾病等发病率疾病。有趣的是，在慢性炎症性疾病中，一些炎症介质可以直接或间接地在胰岛素抵抗的发展中发挥关键作用。这可以被认为是导致这些患者死亡率和发病率增加的另一个因素。在本文中，我们希望调查和比较炎症性肠病（IBD）患者和健康对照组的胰岛素抵抗状况，以及溃疡性结肠炎（UC）和克罗恩病（CD）患者的不同阶段。
本研究共纳入 180 例患者；其中 95 例患有炎症性肠病[克罗恩病（n）：47 例，溃疡性结肠炎（n）：48 例]，85 例为健康对照组。胰岛素抵抗状态采用 HOMA-IR（胰岛素抵抗评估的止血模型）指数进行评估。p<0.05 被认为具有统计学意义。
发现 IBD 和对照组以及克罗恩病和对照组的平均 HOMA-IR 水平相似（p=0.174，p=0.96）；但溃疡性结肠炎（IBD 亚组之一）的平均 HOMA-IR 评分明显高于对照组（p<0.039）。
本研究清楚地表明，溃疡性结肠炎患者的胰岛素抵抗增加。因此，溃疡性结肠炎患者应接受随访，并密切监测其胰岛素抵抗、代谢综合征、糖尿病和心血管疾病的发生。因此，所有这些都会在这些患者中导致发病率和死亡率的额外风险。
