Cordonnier J A, Van den Heede M A, Heyndrickx A M
J Toxicol Clin Toxicol. 1986;24(6):503-17. doi: 10.3109/15563658608995390.
In vitro studies were carried out in order to determine the adsorption of tilidine HCl, a narcotic analgesic, by activated charcoal (max. adsorption capacity 185.5 mg/g of charcoal). The path of the adsorption isotherms at pH 1.2 and 7.5 suggests that the in vivo adsorption of tilidine HCl may be increased when the drug passes from the stomach to the intestine, unless the intestinal content exerts a displacing effect. Nevertheless, the adsorption was dependent on the quantity of activated charcoal used, becoming more complete when the quantity of activated charcoal was increased. The effects of additives on the adsorption capacity of activated charcoal were also investigated in vitro. Ethanol, sorbitol and sucrose significantly reduced drug adsorption, while cacao powder, milk and starch had no effect on tilidine adsorption. At an acid pH, Federa Activated Charcoal significantly adsorbed more drug than either Norit A or Activated Charcoal Merck.
为了确定麻醉性镇痛药盐酸替利定被活性炭（最大吸附容量为185.5毫克/克活性炭）的吸附情况，进行了体外研究。在pH 1.2和7.5条件下吸附等温线的走向表明，当药物从胃进入肠道时，盐酸替利定的体内吸附可能会增加，除非肠内容物产生置换作用。然而，吸附取决于所用活性炭的量，活性炭用量增加时吸附会更完全。还在体外研究了添加剂对活性炭吸附容量的影响。乙醇、山梨醇和蔗糖显著降低了药物吸附，而可可粉、牛奶和淀粉对替利定吸附没有影响。在酸性pH条件下，费德拉活性炭比诺芮特A或默克活性炭显著吸附更多药物。
