State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
J Agric Food Chem. 2022 Jul 6;70(26):7929-7940. doi: 10.1021/acs.jafc.2c01988. Epub 2022 Jun 22.
Plant viral diseases cause the loss of millions of dollars to agriculture around the world annually. Therefore, the development of highly efficient, ultra-low-dosage agrochemicals is desirable for protecting the health of crops and ensuring food security. Herein, a series of 1,3,4-oxadiazole derivatives bearing an isopropanol amine moiety was prepared, and the inhibitory activity against tobacco mosaic virus (TMV) was assessed. Notably, compound exhibited excellent anti-TMV protective activity with an EC value of 137.7 mg L, which was superior to that of ribavirin (590.0 mg L) and ningnanmycin (248.2 mg L). Moreover, the anti-TMV activity of some compounds could be further enhanced (by up to 5-30%) through supplementation with 0.1% auxiliaries. Biochemical assays suggested that compound could suppress the biosynthesis of TMV and induce the plant's defense response. Given these merits, designed compounds had outstanding bioactivities and unusual action mechanisms and were promising candidates for controlling plant viral diseases.
植物病毒病每年给全世界的农业造成数百万美元的损失。因此，开发高效、超低剂量的农用化学品对于保护作物健康和确保粮食安全是可取的。在此，合成了一系列含有异丙醇胺部分的 1,3,4-噁二唑衍生物，并评估了它们对烟草花叶病毒 (TMV) 的抑制活性。值得注意的是，化合物 表现出优异的抗 TMV 保护活性，EC 值为 137.7 mg L，优于利巴韦林（590.0 mg L）和宁南霉素（248.2 mg L）。此外，通过添加 0.1%助剂，一些化合物的抗 TMV 活性可以进一步提高（提高 5-30%）。生化分析表明，化合物 可以抑制 TMV 的生物合成并诱导植物的防御反应。鉴于这些优点，设计的化合物具有出色的生物活性和不寻常的作用机制，是控制植物病毒病的有前途的候选物。
