全肺灌洗治疗尘肺病的疗效：系统评价和荟萃分析。
The Effectiveness of Whole Lung Lavage in Pneumoconiosis: A Systematic Review and Meta-Analysis.
机构信息
From the Internal Medicine Residency Program, Cleveland Clinic Akron General, Akron, Ohio (Dr Zeng); Internal Medicine Primary Care Residency Program, AdventHealth Orlando Medical Center, Orlando, Florida (Dr Jiang); and Veterans Administration Medical Center, Orlando, Florida (Dr Banks).
出版信息
J Occup Environ Med. 2022 Aug 1;64(8):e492-e499. doi: 10.1097/JOM.0000000000002599. Epub 2022 Jun 21.
OBJECTIVE
This study aimed to evaluate the role of whole lung lavage (WLL) in the treatment of pneumoconiosis and compare changes in lung function over time in treated and untreated miners.
METHODS
We systematically reviewed and identified eight controlled studies with treated and comparison groups with lung function tests before WLL and a year or more later. Two hundred ninety-two patients were included in our meta-analysis.
RESULTS
Studies consistently showed a slowing of the rate of lung function decline with WLL at 1, 2, and 4 years. In some reports, details of the population under study, reliability of lung function tests, the adequacy of matching, technical aspects of the procedure, and adverse effects associated with WLL were not available.
CONCLUSIONS
Despite recognized weaknesses in the presentation of information, this procedure may show promise in altering the natural history of pneumoconiosis.
目的
本研究旨在评估全肺灌洗（WLL）在尘肺病治疗中的作用，并比较治疗和未治疗矿工的肺功能随时间的变化。
方法
我们系统地回顾和确定了八项对照研究，这些研究有治疗组和对照组，在 WLL 前和 1 年或更长时间后进行了肺功能测试。我们的荟萃分析纳入了 292 名患者。
结果
研究一致表明，WLL 可减缓 1、2 和 4 年内的肺功能下降速度。在一些报告中，研究人群的细节、肺功能测试的可靠性、匹配的充分性、手术的技术方面以及与 WLL 相关的不良反应并不清楚。
结论
尽管在信息呈现方面存在明显的不足，但该方法可能有望改变尘肺病的自然病程。
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