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接受持续类固醇治疗的 3 岁欧亚犬的脊柱硬膜外和滑膜脂肪化生。

Spinal epidural and synovial lipomatosis in a 3-year-old Eurasian dog receiving sustained steroid therapy.

机构信息

Department of Neurology, CHV Frégis, Arcueil, France.

Department of Diagnostic Imaging, CHV Frégis, Arcueil, France.

出版信息

Vet Med Sci. 2022 Jul;8(4):1373-1377. doi: 10.1002/vms3.842. Epub 2022 Jun 22.

DOI:10.1002/vms3.842
PMID:35732060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9297791/
Abstract

This report describes a spinal cord epidural and synovial lipomatosis in a 3-year-old neutered male Eurasian dog. This dog presented for ambulatory paraparesis and was previously treated with immunosuppressive dosages of prednisolone for 2 years. Computed tomography (CT) myelography and magnetic resonnance imaging (MRI) images identified dorsal compression of the thoraco-lumbar spinal cord by hypertrophic epidural fat. Histological examination identified extensive well-differentiated mature adipose tissue in the subepithelial area of the tarsal synovium. Prednisolone is a reported predisposing factor in humans with lipomatosis.

摘要

本报告描述了一只 3 岁已去势雄性欧亚犬的脊髓硬膜外和滑膜脂肪瘤病。这只狗表现为可移动性后肢轻瘫，此前曾接受 2 年免疫抑制剂量的泼尼松龙治疗。计算机断层扫描 (CT) 脊髓造影和磁共振成像 (MRI) 图像显示，胸腰椎脊髓背侧受压，硬膜外脂肪肥厚。组织学检查发现跗关节滑膜的上皮下区域有广泛的分化良好的成熟脂肪组织。泼尼松龙是人类脂肪瘤病的报道诱发因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/93e353d8cf06/VMS3-8-1373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/5155d59966f9/VMS3-8-1373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/491f5cb29cc0/VMS3-8-1373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/95ce97c6591f/VMS3-8-1373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/93e353d8cf06/VMS3-8-1373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/5155d59966f9/VMS3-8-1373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/491f5cb29cc0/VMS3-8-1373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/95ce97c6591f/VMS3-8-1373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a35/9297791/93e353d8cf06/VMS3-8-1373-g001.jpg

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MRI Features and Clinical Significance of Spinal Epidural Lipomatosis: All You Should Know.脊髓硬膜外脂肪增多症的MRI特征及临床意义：你应知晓的一切。
Curr Med Imaging. 2022;18(2):208-215. doi: 10.2174/1573405617666210824111305.
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Obesity is a risk factor for epidural lipomatosis: a meta-analysis.肥胖是硬膜外脂肪增多症的一个风险因素：一项荟萃分析。
J Orthop Surg (Hong Kong). 2021 May-Aug;29(2):23094990211027391. doi: 10.1177/23094990211027391.
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Extensive Fatty Replacement of the Pancreas (Pancreatic Lipomatosis) in a Dog.一只犬胰腺的广泛脂肪替代（胰腺脂肪过多症）
J Comp Pathol. 2019 Nov;173:19-23. doi: 10.1016/j.jcpa.2019.09.010. Epub 2019 Oct 31.
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Spinal Epidural Lipomatosis: A Review of Pathogenesis, Characteristics, Clinical Presentation, and Management.脊髓硬膜外脂肪增多症：发病机制、特征、临床表现及治疗综述
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Pathology in Practice.实践中的病理学
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Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome.脊柱硬膜外脂肪增多症是代谢综合征的一种先前未被认识的表现形式。
Spine J. 2019 Mar;19(3):493-500. doi: 10.1016/j.spinee.2018.07.022. Epub 2018 Aug 2.
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Results of Arthroscopic Synovectomy for Treatment of Synovial Lipomatosis (Lipoma Arborescens) of the Knee.关节镜下滑膜切除术治疗膝关节滑膜脂肪瘤病（树枝状脂肪瘤）的结果
J Knee Surg. 2018 Jul;31(6):536-540. doi: 10.1055/s-0037-1604440. Epub 2017 Jul 24.
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Potential Involvement of Obesity-Associated Chronic Inflammation in the Pathogenesis of Idiopathic Spinal Epidural Lipomatosis.肥胖相关慢性炎症在特发性脊柱硬膜外脂肪增多症发病机制中的潜在作用。
Spine (Phila Pa 1976). 2016 Dec 1;41(23):E1402-E1407. doi: 10.1097/BRS.0000000000001646.
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