Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Department of Gynaecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, China.
J Obstet Gynaecol Res. 2022 Sep;48(9):2405-2418. doi: 10.1111/jog.15325. Epub 2022 Jun 22.
There have been a large number of epidemiologic studies regarding the association between genetic polymorphisms in DNA repair genes and onset of cervical cancer. However, results are inconsistent.
Articles published before June 2021 and regarding genetic polymorphisms in DNA repair genes and cervical cancer were searched in following databases: PubMed, Web of Science, Google Scholar, and CNKI. With at least three articles for each polymorphism, we made meta-analysis to compute multivariate odds ratios (ORs) and their 95% confidence intervals (CIs).
The present study showed significant associations between XRCC1 Arg399Gln polymorphisms and risk of cervical cancer in Asian, whereas no significant association between them were showed in Caucasian (Asian: GA vs. GG: OR = 1.27, 95%CI 1.06-1.52; AA vs. GG: OR = 1.91, 95%CI 1.29-2.83; GA + AA vs. GG: OR = 1.36, 95%CI 1.12-1.65; AA vs. GG + GA: OR = 1.66, 95%CI 1.17-2.37; Caucasian: GA vs. GG: OR = 1.08, 95%CI 0.83-1.41; AA vs. GG: OR = 2.18, 95%CI 0.75-6.31; GA + AA vs. GG: OR = 1.23, 95%CI 0.85-1.78; AA vs. GG + GA: OR = 1.70, 95%CI 0.69-4.18). In addition, there were significant associations between ERCC2 rs13181 polymorphisms and risk of cervical cancer in Asian (AC vs AA: OR = 0.53, 95%CI 0.37-0.75, I = 0.0%, p value of Q test = 0.847; AC + CC vs AA: OR = 0.50, 95%CI 0.36-0.70, I = 0.0%, p value of Q test = 0.856).
The meta-analysis showed that there were significant associations between XRCC1 Arg399Gln and ERCC2 rs13181 polymorphisms and risk of cervical cancer.
有大量关于 DNA 修复基因遗传多态性与宫颈癌发病风险之间关联的流行病学研究。然而，结果并不一致。
检索了 2021 年 6 月之前发表的关于 DNA 修复基因遗传多态性与宫颈癌的文章，检索数据库包括：PubMed、Web of Science、Google Scholar 和中国知网（CNKI）。对于每种多态性，至少有三篇文章进行了荟萃分析，以计算多变量比值比（OR）及其 95%置信区间（CI）。
本研究显示，XRCC1Arg399Gln 多态性与亚洲人群宫颈癌发病风险之间存在显著关联，而在高加索人群中则无显著关联（亚洲人群：GA 与 GG：OR=1.27，95%CI 1.06-1.52；AA 与 GG：OR=1.91，95%CI 1.29-2.83；GA+AA 与 GG：OR=1.36，95%CI 1.12-1.65；AA 与 GG+GA：OR=1.66，95%CI 1.17-2.37；高加索人群：GA 与 GG：OR=1.08，95%CI 0.83-1.41；AA 与 GG：OR=2.18，95%CI 0.75-6.31；GA+AA 与 GG：OR=1.23，95%CI 0.85-1.78；AA 与 GG+GA：OR=1.70，95%CI 0.69-4.18）。此外，ERCC2rs13181 多态性与亚洲人群宫颈癌发病风险之间也存在显著关联（AC 与 AA：OR=0.53，95%CI 0.37-0.75，I=0.0%，Q 检验 p 值=0.847；AC+CC 与 AA：OR=0.50，95%CI 0.36-0.70，I=0.0%，Q 检验 p 值=0.856）。
荟萃分析表明，XRCC1Arg399Gln 和 ERCC2rs13181 多态性与宫颈癌发病风险之间存在显著关联。
