X 射线修复交叉互补基因 1（XRCC1）遗传多态性与宫颈癌风险：一项大型系统评价和荟萃分析。
X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis.
机构信息
Division of Reproductive Medical Center, West China Second University Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
出版信息
PLoS One. 2012;7(9):e44441. doi: 10.1371/journal.pone.0044441. Epub 2012 Sep 12.
BACKGROUND
Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results. The aim of our study was to assess the association between the XRCC1 gene Arg399Gln, Arg194Trp, Arg280His polymorphisms and risk of CC.
METHODS
Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Databases for studies published before March 2011.Summary odds ratios (ORs) and 95% confidence intervals (CIs) for XRCC1 polymorphisms and CC were calculated in a fixed-effects model or a random-effects model when appropriate.
RESULTS
Ultimately, 9, 5 and 2 studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp and Arg280His, respectively. Our analysis suggested that the variant genotypes of Arg194Trp were associated with a significantly increased CC risk (Trp/Trp vs Arg/Arg, OR = 2.21, 95% CI = 1.60-3.06; Arg/Trp vs Arg/Arg, OR = 1.23, 95% CI = 1.02-1.49; dominant model, OR = 1.36, 95% CI = 1.14-1.63; recessive model, OR = 2.06, 95% CI = 1.51-2.82). For Arg280His polymorphism, no obvious associations were found for all genetic models. For Arg399Gln polymorphism, also no obvious associations were found for all genetic models. In the subgroup analyses by ethnicity/country, a significantly increased risk was observed among Asian, especially among Chinese. To get more precise evidences, adjusted ORs (95%CI) by potential confounders (such as age, ethnicity or smoking, etc) were also calculated for XRCC1 Arg399Gln and Arg194Trp, however, the estimated pooled adjusted OR still did not change at all.
CONCLUSION
This meta-analysis suggests that Arg194Trp polymorphism may be associated with CC risk, Arg399Gln polymorphism might be a low-penetrent risk factor for CC only in Asians, and there may be no association between Arg280His polymorphism and CC risk.
背景
先前研究探讨 X 射线修复交叉互补基因 1（XRCC1）多态性与宫颈癌（CC）风险之间的关系，结果并不一致。本研究旨在评估 XRCC1 基因 Arg399Gln、Arg194Trp、Arg280His 多态性与 CC 风险的关系。
方法
两位研究者独立检索了 Medline、Embase、中国知网（CNKI）和中国生物医学文献数据库，以获取截至 2011 年 3 月前发表的研究。采用固定效应模型或随机效应模型计算 XRCC1 多态性与 CC 之间的汇总比值比（OR）及其 95%置信区间（CI）。
结果
最终，分别有 9 项、5 项和 2 项研究纳入 Arg399Gln、Arg194Trp 和 Arg280His 多态性的 meta 分析。分析结果提示，Arg194Trp 的变异基因型与 CC 风险显著增加相关（Trp/Trp 与 Arg/Arg 相比，OR=2.21，95%CI=1.60-3.06；Arg/Trp 与 Arg/Arg 相比，OR=1.23，95%CI=1.02-1.49；显性模型，OR=1.36，95%CI=1.14-1.63；隐性模型，OR=2.06，95%CI=1.51-2.82）。对于 Arg280His 多态性，所有遗传模型均未发现明显相关性。对于 Arg399Gln 多态性，所有遗传模型也未发现明显相关性。在按种族/国家进行的亚组分析中，亚洲人群，尤其是中国人，观察到风险显著增加。为获得更精确的证据，还按潜在混杂因素（如年龄、种族或吸烟等）校正了 XRCC1 Arg399Gln 和 Arg194Trp 的调整 OR（95%CI），但估计的合并调整 OR 没有任何变化。
结论
本 meta 分析提示 Arg194Trp 多态性可能与 CC 风险相关，Arg399Gln 多态性可能仅在亚洲人群中是 CC 的低外显度风险因素，Arg280His 多态性与 CC 风险可能无关。
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