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新冠后鼻脑型毛霉菌病:第二波疫情期间的一项观察性研究

Post-Covid-19 Rhino-Cerebral Mucormycosis: an Observational Study During the Second Wave.

作者信息

Sajjan Anandkumar, Nimbal Anand V, Shahapur Roopa, Bagoji Ishwar B, Chiniwar Vinutha A, Chillalashetti Sreedevi K

机构信息

Department of Dentistry, BLDEDU, Vijayapura Karnataka, India.

Department of Anatomy, BLDEDU, Vijayapura Karnataka, India.

出版信息

Maedica (Bucur). 2022 Mar;17(1):103-106. doi: 10.26574/maedica.2022.17.1.103.

Abstract

Mucormycosis is one of the most lethal and rapidly spreading fungal infection which is caused by fungus of the order . The swiftness of spreading and high mortality rate that characterize mucormycosis cases added more burden to the enormous challenge brought by the Covid-19 pandemic globally. The aim of this article is to identify and discuss mucormycosis and review the literature related to its diagnosis and management. A total of 15 mucormycosis cases with a history of Covid-19 infection were identified in the Department of Dentistry of Shri B M Patil Medical College Hospital and Research Centre BLDE (Deemed to be University), Vijayapura, India. The duration of the study was between April 1st and mid-September 2021. Nasal swab and tissue samples from oral and maxillofacial region were collected. Blood investigations, RT-PCR and HbA1c tests and radiography revealed changes in the trabecular pattern and bone loss associated with periodontal inflammation. Mucormycosis is a life-threatening infection. Hence, dental and other clinical professionals must be aware of this possible fatal complication, so as to avoid an unfavorable outcome in clinical practice.

摘要

毛霉病是由毛霉目真菌引起的最致命且传播迅速的真菌感染之一。毛霉病病例所具有的传播速度快和死亡率高的特点,给全球范围内新冠疫情带来的巨大挑战增添了更多负担。本文旨在识别和探讨毛霉病,并综述其诊断和治疗的相关文献。在印度维杰亚普拉的斯里·B·M·帕蒂尔医学院医院及研究中心BLDE(被视为大学)牙科学院,共识别出15例有新冠病毒感染病史的毛霉病病例。研究时间为2021年4月1日至9月中旬。采集了鼻拭子以及口腔和颌面区域的组织样本。血液检查、逆转录聚合酶链反应和糖化血红蛋白检测以及影像学检查显示,骨小梁模式发生改变以及存在与牙周炎症相关的骨质流失。毛霉病是一种危及生命的感染。因此,牙科及其他临床专业人员必须了解这种可能致命的并发症,以便在临床实践中避免出现不良后果。

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Rhino-Orbito-Cerebral Mucormycosis During the Second Wave of Covid-19: The Indian Scenario.新冠疫情第二波期间的鼻眶脑型毛霉菌病:印度的情况
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):3492-3497. doi: 10.1007/s12070-021-02978-y. Epub 2021 Nov 12.
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Mucormycosis: An opportunistic pathogen during COVID-19.毛霉菌病:COVID-19 期间的机会性病原体。
Environ Res. 2021 Oct;201:111643. doi: 10.1016/j.envres.2021.111643. Epub 2021 Jul 6.
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The recent mucormycosis storm over Indian sky.近期毛霉菌病风暴笼罩印度上空。
Indian J Med Microbiol. 2021 Jul;39(3):269-270. doi: 10.1016/j.ijmmb.2021.06.010. Epub 2021 Jun 24.
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Origin and evolution of pathogenic coronaviruses.致病冠状病毒的起源与演化。
Nat Rev Microbiol. 2019 Mar;17(3):181-192. doi: 10.1038/s41579-018-0118-9.
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Mucormycosis causing maxillary osteomyelitis.毛霉菌病引发上颌骨骨髓炎。
J Nat Sci Biol Med. 2015 Jul-Dec;6(2):456-9. doi: 10.4103/0976-9668.160039.

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