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糖尿病患者由[具体病原体1]和[具体病原体2]引起的混合性皮肤和软组织感染:病例报告

Mixed Skin and Soft Tissue Infection Caused by and in a Diabetic Patient: A Case Report.

作者信息

Ioannou Petros, Chatzisymeon Despoina, Maraki Sofia, Samonis George, Kofteridis Diamantis P

机构信息

Department of Internal Medicine, University Hospital of Heraklion, Crete, Greece.

Department of Microbiology, University Hospital of Heraklion, Crete, Greece.

出版信息

Maedica (Bucur). 2022 Mar;17(1):211-214. doi: 10.26574/maedica.2022.17.1.211.

Abstract

is a widely distributed fungus that has evolved as an important pathogen, especially in immunocompromised individuals, causing fungemias, central nervous system infections, peritoneal dialysis-associated peritonitis and keratitis. Even though there are a few reports of skin and soft tissue infections caused by , all these cases involve immunocompromised individuals. is a Gram-positive bacterium known to cause several infections such as bloodstream, urinary tract and skin and soft tissue infections. We report a mixed and skin and soft tissue infection in a 63-year-old woman with well controlled type 2 diabetes mellitus and no other known history of immunosuppression, suffering from skin and soft tissue infection of the right lower extremity. The patient did not respond to treatment with broad spectrum antimicrobials, but had a successful outcome with fluconazole, after was isolated from pus of the skin ulcer. The antifungal treatment led to eradication of the infection, while no recurrence was observed during a follow-up period of two years. Clinicians should be aware that can cause infection even in immunocompetent patients.

摘要

是一种广泛分布的真菌,已演变成一种重要的病原体,尤其是在免疫功能低下的个体中,可引起真菌血症、中枢神经系统感染、腹膜透析相关性腹膜炎和角膜炎。尽管有一些关于由引起的皮肤和软组织感染的报道,但所有这些病例都涉及免疫功能低下的个体。是一种革兰氏阳性细菌,已知可引起多种感染,如血流感染、尿路感染以及皮肤和软组织感染。我们报告了一名63岁2型糖尿病控制良好且无其他已知免疫抑制病史的女性发生的混合性和皮肤及软组织感染,该患者患有右下肢皮肤和软组织感染。患者对广谱抗菌药物治疗无反应,但在从皮肤溃疡脓液中分离出后,使用氟康唑治疗取得了成功。抗真菌治疗导致感染根除,在两年的随访期内未观察到复发。临床医生应意识到即使在免疫功能正常的患者中也可引起感染。

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本文引用的文献

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[A skin ulcer infection due to Rhodotorula mucilaginosa in an immunocompromised child].
J Mycol Med. 2018 Mar;28(1):215-217. doi: 10.1016/j.mycmed.2018.01.006. Epub 2018 Mar 15.

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