Motawea Karam R, Kandil Omneya A, Varney Joseph, Aboelenein Merna, Ibrahim Nancy, Shaheen Ahmed, Khairy Lina T, Bakkour Agyad, Muwaili Ali H H, Muwaili Dhuha H H, Abdelmajid Fatima A A, Ahmad Eman M S, Albuni Mhd K, Battikh Elias, Sawaf Bisher, Swed Sarya, Ahmed Safaa M A, Awad Dina M, Shah Jaffer, Aiash Hani
Faculty of Medicine Alexandria University Alexandria Egypt.
School of Medicine American University of the Caribbean Cupecoy Sint Maarten.
Health Sci Rep. 2022 Jun 13;5(4):e693. doi: 10.1002/hsr2.693. eCollection 2022 Jul.
Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta-analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose tissue thickness.
We searched the following databases: PUBMED, WOS, OVID, SCOPUS, and EMBASE. Inclusion criteria were any original articles that reported epicardial adipose tissue in FMF patients with no age restriction, excluding reviews, case reports, editorials, animal studies, and non-English studies. Thirty eligible studies were screened full text but only five studies were suitable. We used RevMan software (5.4) for the meta-analysis.
The total number of patients included in the meta-analysis in the FMF patients group is 256 (mean age = 24.3), and the total number in the control group is 188 (mean age = 24.98). The pooled analysis between FMF patients and controls was [mean difference = 0.82 (95% CI = 0.25-1.39), -value = 0.005]. We observed heterogeneity that was not solved by random effects ( > 0.00001). We performed leave one out test by removing the Kozan et al. study, and the heterogeneity was solved ( = 0.07), and the results were (MD = 0.98, 95% CI = 0.52-1.43, -value < 0.0001).
FMF patients are at increased risk of developing epicardial adipose tissue compared to controls. More multicenter studies with higher sample sizes are needed to support our results.
一些研究报道家族性地中海热（FMF）与心外膜脂肪组织之间存在正向关联。我们的荟萃分析旨在评估FMF与心外膜脂肪组织厚度增加之间是否存在显著关联。
我们检索了以下数据库：PUBMED、WOS、OVID、SCOPUS和EMBASE。纳入标准为任何报道FMF患者心外膜脂肪组织的原创文章，无年龄限制，排除综述、病例报告、社论、动物研究和非英文研究。筛选出30项符合条件的研究进行全文阅读，但只有5项研究合适。我们使用RevMan软件（5.4）进行荟萃分析。
FMF患者组纳入荟萃分析的患者总数为256例（平均年龄=24.3岁），对照组总数为188例（平均年龄=24.98岁）。FMF患者与对照组的汇总分析结果为[平均差异=0.82（95%CI=0.25-1.39），P值=0.005]。我们观察到存在异质性，随机效应未能解决该问题（I²>0.00001）。我们通过剔除Kozan等人的研究进行留一法检验，异质性得到解决（I²=0.07），结果为（MD=0.98，95%CI=0.52-1.43，P值<0.0001）。
与对照组相比，FMF患者发生心外膜脂肪组织的风险增加。需要更多样本量更大的多中心研究来支持我们的结果。
