1Department of Pediatrics, University Hospital Center Sestre milosrdnice, Zagreb, Croatia;2Department of Neurology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia.
Acta Clin Croat. 2021 Dec;60(4):595-601. doi: 10.20471/acc.2021.60.04.05.
Apolipoprotein E (APOE) plays an important role in lipid metabolism and is a proven risk factor for development of dementia and other neurodegenerative diseases. The aim of the study was to determine the possible connection between particular APOE alleles, blood lipid profile and different types of epilepsy in children. Alleles of the APOE gene, blood cholesterol (total, high-density lipoprotein and low-density lipoprotein (LDL) cholesterol, and triglyceride levels were analyzed in blood samples of 111 children with epilepsy and 118 age- and sex-matched children without epilepsy. Distribution of APOE genotypes was the same in children of both groups. Significantly increased levels of total cholesterol and LDL cholesterol were found in control group (Z=3.49 and 3.52 respectively, p<0.01). No statistically significant difference was found between the genotypes of children with idiopathic and symptomatic epilepsy (χ=1.96; df=2; p>0.05). There were statistically significant differences in the levels of total cholesterol (Z=2.09; p<0.05) and LDL cholesterol (Z=2.05; p<0.05) according to the type of epilepsy in favor of symptomatic epilepsy. The study confirmed that there was no connection between APOE and type of epilepsy in children and showed the children with epilepsy to have lower total cholesterol and LDL cholesterol levels. Interestingly, this also held true for children with idiopathic epilepsy compared to those with symptomatic condition.
载脂蛋白 E (APOE) 在脂质代谢中发挥重要作用，是痴呆症和其他神经退行性疾病发展的已证实的风险因素。本研究旨在确定特定 APOE 等位基因、血脂谱与儿童不同类型癫痫之间的可能联系。在 111 例癫痫患儿和 118 例年龄和性别匹配的无癫痫患儿的血液样本中分析了 APOE 基因的等位基因、血胆固醇（总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇[LDL]胆固醇和甘油三酯水平。两组儿童的 APOE 基因型分布相同。对照组总胆固醇和 LDL 胆固醇水平显著升高（Z=3.49 和 3.52，均 p<0.01）。特发性和症状性癫痫患儿的基因型之间无统计学差异（χ=1.96；df=2；p>0.05）。总胆固醇（Z=2.09；p<0.05）和 LDL 胆固醇（Z=2.05；p<0.05）水平根据癫痫类型存在统计学差异，有利于症状性癫痫。该研究证实 APOE 与儿童癫痫类型之间无关联，并表明癫痫患儿的总胆固醇和 LDL 胆固醇水平较低。有趣的是，与有症状的患儿相比，特发性癫痫患儿的情况也是如此。
