Wang Hongyu, Li Chaonan, Wu Qihang, Wen Hui, Sun Tingting, Xie Zhigang
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
School of Applied Chemistry and Engineering University of Science and Technology of China, Hefei 230026, P. R. China.
J Mater Chem B. 2022 Jul 6;10(26):4967-4973. doi: 10.1039/d2tb00778a.
On account of the constant evolution of antibiotic-resistant bacteria, the effects of existing antibacterial materials are being gradually weakened, and the difficulty in curing infectious diseases is increasing. Therefore, more novel antibacterial materials or methods are eagerly required to combat microbial infections. Recently, the advantages of photodynamic therapy in the antibacterial field have gradually been validated. Herein, a trimethylamine (TMA) salt-modified 4,4-difluoro-4-bora-3,4-diaza--indacene (BODIPY) photosensitizer (BODIPY-TMA) was synthesized for antibacterial applications. Due to the positive charge of the TMA group, enhanced interactions were observed between the prepared BODIPY-TMA nanoparticles (BODIPY-TMA NPs) and negatively-charged bacterial membranes. The BODIPY-TMA NPs showed much better antibacterial effect toward both and compared with their BODIPY-Br NPs counterpart without a positive charge. Moreover, the BODIPY-TMA NPs efficiently prevented the formation of biofilms and destroyed pre-established biofilms. Thus, such positively-charged photosensitizers may pave the way for the exploration of highly effective antibacterial agents.
由于耐药细菌的不断进化，现有抗菌材料的效果正逐渐减弱，治疗传染病的难度也在增加。因此，迫切需要更多新型抗菌材料或方法来对抗微生物感染。最近，光动力疗法在抗菌领域的优势已逐渐得到验证。在此，合成了一种三甲胺（TMA）盐修饰的4,4-二氟-4-硼-3,4-二氮杂-吲哚碳菁（BODIPY）光敏剂（BODIPY-TMA）用于抗菌应用。由于TMA基团带正电荷，观察到制备的BODIPY-TMA纳米颗粒（BODIPY-TMA NPs）与带负电荷的细菌膜之间的相互作用增强。与不带正电荷的BODIPY-Br NPs相比，BODIPY-TMA NPs对[此处原文缺失两种细菌名称]均表现出更好的抗菌效果。此外，BODIPY-TMA NPs能有效防止生物膜的形成并破坏预先形成的生物膜。因此，这种带正电荷的光敏剂可能为探索高效抗菌剂铺平道路。
