术后镇痛泵应用于肺癌患者肺叶切除术后恶心呕吐的发生率及危险因素分析。
Incidence and risk factors of postoperative nausea and vomiting in lung cancer patients following lobectomy and application of analgesic pumps.
机构信息
Department of Thoracic Surgery, Sun Yat-sen University Cancer Centre; State Key Laboratory of Oncology in South China; Collaborative Innovation Centre for Cancer Medicine; Guangzhou, China.
Department of Radiology, Sun Yat-sen University Cancer Centre; State Key Laboratory of Oncology in South China; Collaborative Innovation Centre for Cancer Medicine; Guangzhou, China.
出版信息
J Int Med Res. 2022 Jun;50(6):3000605221105343. doi: 10.1177/03000605221105343.
OBJECTIVE
To investigate the occurrence rate and risk factors of postoperative nausea and vomiting (PONV) in lung cancer patients following lobectomy and application of analgesic pumps.
METHODS
This retrospective study reviewed clinical data from patients that had undergone lobectomy for lung cancer under general anaesthesia. The risk factors of PONV were analysed using binary logistic regression models.
RESULTS
A total of 203 patients (97 females) were enrolled. The rate of PONV was 29.6% (60 of 203 patients) for all patients, 42.3% (41 of 97 patients) for female patients and 17.9% (19 of 106 patients) for male patients. Female patients undergoing thoracotomy (odds ratio [OR] 7.770, 95% confidence interval [CI] 1.747, 34.568) or having surgery durations ≥120 min (OR 4.493, 95% CI 1.502, 12.851) were significantly more susceptible to PONV. The risk of PONV in female patients that received postoperative dolasetron (100 mg, once a day) was significantly lower (OR 0.075, 95% CI 0.007, 0.834). For male patients, the risk of PONV was significantly lower in those with a body mass index ≥24 kg/m (OR 0.166; 95% CI 0.035, 0.782).
CONCLUSION
Female and male patients have different risk factors for PONV following lobectomy for lung cancer and application of analgesic pumps.
目的
探讨全肺切除术后应用镇痛泵患者术后恶心呕吐（PONV）的发生率及相关危险因素。
方法
本回顾性研究分析了全麻下行全肺切除术治疗肺癌患者的临床资料。采用二项逻辑回归模型分析 PONV 的危险因素。
结果
共纳入 203 例（97 例女性）患者。所有患者 PONV 发生率为 29.6%（203 例中有 60 例），女性患者为 42.3%（97 例中有 41 例），男性患者为 17.9%（106 例中有 19 例）。女性患者行开胸手术（比值比 [OR] 7.770，95%置信区间 [CI] 1.747，34.568）或手术时间≥120 min（OR 4.493，95% CI 1.502，12.851）者 PONV 发生率显著升高。术后接受多拉司琼（100 mg，1 次/d）治疗的女性患者 PONV 风险显著降低（OR 0.075，95% CI 0.007，0.834）。对于男性患者，体质指数≥24 kg/m2 者 PONV 风险显著降低（OR 0.166；95% CI 0.035，0.782）。
结论
女性和男性肺癌患者全肺切除术后应用镇痛泵发生 PONV 的危险因素不同。
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