National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.
Mult Scler. 2022 Aug;28(9):1481-1484. doi: 10.1177/13524585221090737. Epub 2022 Jun 23.
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
To report progressive disease in a patient with MOGAD.
A single retrospective case report.
At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
Secondary progression may be a rare presentation of MOG-IgG-associated disease.
髓鞘少突胶质细胞糖蛋白抗体相关性疾病（MOGAD）可能与复发疾病相关，但与复发活动无关的临床进展较为罕见。
报告 1 例 MOGAD 患者的进行性疾病。
单例回顾性病例报告。
4 岁时，患者发生了单次急性播散性脑脊髓炎。她一直保持良好，直到 17 岁，但在接下来的 9 年中，她逐渐出现痉挛性四肢瘫痪、认知和球部功能障碍。脑部影像学显示出一种白质异常的脱髓鞘样模式，不同时间点有对比增强。髓鞘少突胶质细胞糖蛋白（MOG）-IgG 反复通过活细胞检测呈阳性。
继发性进展可能是 MOG-IgG 相关性疾病的一种罕见表现。
