Department of Physical Medicine and Rehabilitation, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan; Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Biomed J. 2021 Dec;44(6 Suppl 1):S101-S109. doi: 10.1016/j.bj.2020.07.005. Epub 2020 Jul 27.
Unilateral vocal fold paralysis (UVFP) caused by lung surgery is associated with prolonged hospital stay and increased postoperative comorbidities. We evaluated lung surgery-related UVFP and compared its characteristics with UVFP caused by esophageal and thyroid surgeries, as the most common surgical causes of UVFP. We also evaluated the outcomes of intracordal hyaluronate injection laryngoplasty in these patients.
Patients with surgery-related UVFP were evaluated by quantitative laryngeal electromyography, videolaryngostroboscopy, voice acoustic analysis, Voice Outcome Survey (VOS) questionnaire, and Short Form-36 Health Survey (SF-36) quality-of-life questionnaire. Data for the lung, esophageal, and thyroid surgery groups were compared and changes in outcome measurements induced by hyaluronate injection were compared among the three groups.
A total of 141 patients were recruited, including 21, 46, and 74 in the lung, esophageal, and thyroid surgery groups, respectively. Compared with the other two groups, lung surgery patients had predominantly left-sided UVFP, less involvement of the external branch of the superior laryngeal nerve, and higher jitter. Most outcome measurements improved in all three groups after office-based hyaluronate injection, with the greatest improvement in jitter in the lung surgery group.
Lung surgery-related UVFP showed a distinct disease presentation, and patients' voice parameters and quality of life recovered dramatically after office-based hyaluronate injection. We recommend evaluation of lung surgery-related UVFP and early intervention, such as office-based hyaluronate injection, to improve patients' voice function and quality of life.
肺手术引起的单侧声带麻痹（UVFP）与住院时间延长和术后合并症增加有关。我们评估了与肺手术相关的 UVFP，并将其与食管和甲状腺手术引起的 UVFP 进行了比较，因为这是最常见的引起 UVFP 的手术原因。我们还评估了这些患者声带内透明质酸注射成形术的结果。
通过定量喉肌电图、视频喉镜检查、语音声学分析、嗓音结果调查（VOS）问卷和简化 36 健康调查（SF-36）生活质量问卷评估与手术相关的 UVFP 患者。比较了肺、食管和甲状腺手术组的数据，并比较了三组中透明质酸注射引起的结果测量变化。
共招募了 141 名患者，其中肺、食管和甲状腺手术组分别为 21、46 和 74 名。与其他两组相比，肺手术患者主要为左侧 UVFP，较少累及上喉神经外支，且肌颤搐较高。所有三组患者在门诊进行透明质酸注射后，大多数结果测量均有改善，其中肺手术组肌颤搐改善最大。
肺手术相关的 UVFP 表现出明显的疾病表现，患者的嗓音参数和生活质量在门诊进行透明质酸注射后显著改善。我们建议评估与肺手术相关的 UVFP 并进行早期干预，如门诊透明质酸注射，以改善患者的嗓音功能和生活质量。
