Wang Yong, Li Jigai, Zhang Yukun, Nan Yi, Zhou Xin
Department of Chemistry, College of Chemistry and Chemical Engineering, Qingdao University, Shandong, China.
Cancer Institute, the Affiliated Hospital of Qingdao University, Shandong, China.
Chem Commun (Camb). 2022 Jul 12;58(56):7797-7800. doi: 10.1039/d2cc02124b.
Type I photodynamic therapy (PDT) with less oxygen consumption shows great potential to overcome the malignant hypoxia in solid tumors. Herein, a novel meso phosphate-substituted pyronin PY-P and its nanoparticles (PY-P NPs) were prepared as an efficient type I organic photosensitizer. The data prove that PY-P NPs have outstanding low dark toxicity but high photocytotoxicity under hypoxia (<1% O).
耗氧量较低的I型光动力疗法（PDT）在克服实体瘤中的恶性缺氧方面具有巨大潜力。在此，制备了一种新型的中磷酸取代吡咯宁PY-P及其纳米颗粒（PY-P NPs）作为一种高效的I型有机光敏剂。数据证明，PY-P NPs具有出色的低暗毒性，但在低氧（<1% O）条件下具有高光细胞毒性。
