Loukas Georgios, Kosho Madeline X F, Paraskevas Spiros, Loos Bruno G
Department of Periodontology, Academic Centre for Dentistry, Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands.
Dent J (Basel). 2022 Jun 14;10(6):110. doi: 10.3390/dj10060110.
Recent scientific evidence states that a subset of COVID-19 patients may have a risk of increased bleeding tendency. This case report presents a healthy 38-year-old woman with generalized stage III, grade C periodontitis with an abnormal post-operative blood clot formation who tested positive for COVID-19 after a standard periodontal surgery. Previously, two periodontal surgeries proceeded without any complications and were considered standard. On day one after the third periodontal surgery the patient had no complaints. On day two the patient reported excess bleeding in the oral cavity from the operated area simultaneously with fever and loss of taste. On day three the patient was seen in our clinic; general malaise symptoms and bleeding tendency had started to decline and the patient received a COVID-19 PCR test. At day four the test resulted positive, and she reported no further complaints of intraoral bleeding. Six months later the taste of the patient was still distorted. For this patient with free medical anamnesis, we suggest that the patient had increased plasma levels of tissue plasminogen activator during the crucial postoperative period due to an acute COVID-19 infection. This led to increased plasmin levels with a hyper-fibrinolytic state as a consequence.
最近的科学证据表明,一部分新冠病毒肺炎患者可能有出血倾向增加的风险。本病例报告介绍了一名38岁健康女性,患有广泛性III期C级牙周炎,术后血凝块形成异常,在进行标准牙周手术后新冠病毒检测呈阳性。此前,该患者曾进行过两次牙周手术,均无任何并发症,且被视为标准手术。第三次牙周手术后第一天,患者无任何不适。第二天,患者报告手术区域口腔出血过多,同时伴有发热和味觉丧失。第三天,患者前来我们诊所就诊;全身不适症状和出血倾向开始减轻,患者接受了新冠病毒核酸检测。第四天检测结果呈阳性,且患者报告口腔内未再出血。六个月后,患者味觉仍有畸变。对于这名有免费医疗病史的患者,我们认为该患者在关键的术后阶段由于急性新冠病毒感染导致血浆组织型纤溶酶原激活物水平升高。这导致纤溶酶水平升高,进而出现高纤溶状态。