Miranda Agustín Ramiro, Cortez Mariela Valentina, Scotta Ana Veronica, Soria Elio Andrés
Health Sciences Research Institute, National Scientific and Technical Research Council, Córdoba 5014, Argentina.
School of Phonoaudiology, Faculty of Medical Sciences, National University of Córdoba, Córdoba 5014, Argentina.
J Intell. 2022 May 31;10(2):33. doi: 10.3390/jintelligence10020033.
Puerperium may lead to memory and executive/attentional complaints that interfere with women's daily life. This might be prevented by dietary compounds, such as neuroprotective polyphenols. Their bioactivity depends on their effects on lipid metabolism in different tissues, such as the brain, fat, and breast. Thus, a polyphenol-related cognitive improvement may be associated with changes of lipids in human milk, which are key for infant neurodevelopment. A cross-sectional study was conducted on 75 postpartum women from Córdoba (Argentina), involving several neuropsychological tests. Diet was registered to identify polyphenol intake and food pattern adherence, with sociodemographic and other psychological variables (insomnia, stress, subjective cognitive complaints) being also studied. Triacylglycerols, cholesterol, and their oxidative forms were analyzed as milk biomarkers. Multivariate statistical methods were applied. Results confirmed that women who consumed polyphenols presented better executive/attentional performance (i.e., higher correct responses, conceptual level responses, complete categories, verbal fluency; lower attentional interferences, and perseverative errors) and word retention with lower interference. Polyphenols were positively associated with milk lipids, which were higher in women with better cognition. Furthermore, they had lower oxidized triacylglycerols. In conclusion, polyphenolic intake during postpartum may improve executive/attentional functioning, memory, and milk lipid profile.
产褥期可能会导致记忆以及执行/注意力方面的问题，这些问题会干扰女性的日常生活。这可能可以通过膳食化合物来预防，比如具有神经保护作用的多酚类物质。它们的生物活性取决于其对不同组织（如大脑、脂肪和乳腺）脂质代谢的影响。因此，与多酚相关的认知改善可能与母乳中脂质的变化有关，而母乳脂质对婴儿神经发育至关重要。对来自阿根廷科尔多瓦的75名产后女性进行了一项横断面研究，其中涉及多项神经心理学测试。记录饮食情况以确定多酚摄入量和食物模式依从性，同时还研究了社会人口统计学和其他心理变量（失眠、压力、主观认知问题）。分析了三酰甘油、胆固醇及其氧化形式作为母乳生物标志物。应用了多变量统计方法。结果证实，摄入多酚的女性表现出更好的执行/注意力表现（即更高的正确反应、概念水平反应、完整类别、语言流畅性；更低的注意力干扰和持续性错误）以及更低干扰下的单词记忆。多酚与母乳脂质呈正相关，认知较好的女性母乳脂质含量更高。此外，她们的氧化三酰甘油含量更低。总之，产后摄入多酚类物质可能会改善执行/注意力功能、记忆力和母乳脂质状况。
