Tang Philip Chiu-Tsun, Zhang Ying-Ying, Li Jane Siu-Fan, Chan Max Kam-Kwan, Chen Jiaoyi, Tang Ying, Zhou Yiming, Zhang Dongmei, Leung Kam-Tong, To Ka-Fai, Tang Sydney Chi-Wai, Lan Hui-Yao, Tang Patrick Ming-Kuen
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong 999077, China.
Department of Nephrology, Tongji University School of Medicine, Shanghai 200065, China.
Noncoding RNA. 2022 May 25;8(3):36. doi: 10.3390/ncrna8030036.
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed.
转化生长因子-β（TGF-β）是炎症性疾病的关键致病介质。在组织纤维化中，TGF-β调节浸润免疫细胞的致病活性，并通过从头生成肌成纤维细胞和激活肾细胞来促进细胞外基质的产生。在癌症中，TGF-β通过增强癌细胞的干性和上皮-间质转化来促进癌症侵袭和转移。然而，TGF-β在组织纤维化和癌症中具有高度多效性，因此，直接靶向TGF-β也可能阻断其保护性抗炎和肿瘤抑制作用，从而导致不良后果。越来越多的证据表明，长链非编码RNA（lncRNA）参与了TGF-β驱动的组织纤维化和癌症进展，具有高度的细胞类型和疾病特异性，是治疗开发的理想靶点。在这篇综述中，将讨论TGF-β相关lncRNA在组织纤维化和癌症中的机制及转化潜力。
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