School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5371, Australia.
Department of Jobs, Precincts and Regions, Agribio, The Centre for AgriBioscience, Melbourne, VIC 3083, Australia.
Toxins (Basel). 2022 Jun 17;14(6):414. doi: 10.3390/toxins14060414.
Acute bovine liver disease (ABLD) is a hepatic disease affecting cattle sporadically in southern Australia, characterised histologically by striking periportal hepatocellular necrosis. The cause of ABLD is unknown; however, the seasonality and acute presentation of outbreaks suggest mycotoxin involvement. We described the geographical and seasonal occurrence of ABLD reports from 2010 to 2020 in Victoria, Australia, and explored potential weather triggers preceding 26 outbreaks occurring across 23 properties using a case-crossover design. Outbreaks occurred most frequently in autumn/early winter and in herds located along the southern coastal plain of Victoria, and occasionally within the low-lying regions of the Great Dividing Range. Lactating adult dairy cattle represented the most reported cases. We observed a significant association between an increase in average daily dewpoint in the 15 days preceding an ABLD outbreak, suggesting that dew formation may be a key determinant for this disease. Our findings support the etiology of a potent hepatotoxic agent that requires moisture for proliferation and/or toxin production.
急性牛肝病（ABLD）是一种偶发性肝脏疾病，影响澳大利亚南部的牛群，其组织学特征为明显的门管区肝细胞坏死。ABLD 的病因尚不清楚；然而，疫情的季节性和急性发作表明与霉菌毒素有关。我们描述了 2010 年至 2020 年在澳大利亚维多利亚州发生的 ABLD 报告的地理和季节性分布，并使用病例交叉设计探索了在 23 个牧场的 26 次疫情发生前潜在的天气触发因素。疫情最常发生在秋季/初冬，以及位于维多利亚州南部沿海平原的牛群中，偶尔也发生在大分水岭的低地地区。哺乳期成年奶牛是报告最多的病例。我们观察到在 ABLD 疫情发生前 15 天内平均每日露点增加与疫情之间存在显著关联，这表明露水的形成可能是该疾病的关键决定因素。我们的研究结果支持了一种强有力的肝毒素的病因，这种毒素需要水分才能增殖和/或产生毒素。
