Department of NMR & MRI Facility, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Department of NMR & MRI Facility, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Brain Lang. 2022 Aug;231:105148. doi: 10.1016/j.bandl.2022.105148. Epub 2022 Jun 20.
Auditory perception and associated cognition involve visual and auditory cortical areas for inference of meaningful soundscape.
To investigate auditory perception of ambiguous and non-ambiguous stimulation in auditory and visual cortical networks for categorical discrimination.
Functional mapping was carried out in twenty early (EB), twenty late blind (LB) and fifteen healthy children, during auditory ambiguous and non-ambiguous stimulation task in a 3 T MR scanner to estimate hemodynamic signal alteration and its effect on functional connectivity. The degree of amplitude low-frequency fluctuation (ALFF), correlation analysis and multiple comparison was carried out to map the impact of duration of education and onset of blindness (EB and LB).
Increased functional connectivity (FC) and cross-modal reorganization was observed in auditory, visual and language networks in EB children. FC was increased in contralateral hemisphere in both the blind children (EB and LB) groups and was positively correlated with duration of education performance. Cognitive assessment scores correlated (p < 0.01) with cluster coefficient of FC and BOLD response.
FC alterations depend on onset age and audio-haptic training in children associated with increased auditory language and memory perception.
听觉感知和相关认知涉及视觉和听觉皮质区域，以推断有意义的声景。
研究听觉皮质网络中对模糊和非模糊刺激的听觉感知，以进行类别辨别。
在 3T MR 扫描仪中对二十名早期（EB）、二十名晚期失明（LB）和十五名健康儿童进行功能映射，以估计血流动力学信号变化及其对功能连接的影响。进行幅度低频波动（ALFF）、相关性分析和多重比较，以绘制教育持续时间和失明开始（EB 和 LB）的影响。
在 EB 儿童中观察到听觉、视觉和语言网络中功能性连接（FC）的增加和跨模态重组。在两个盲童（EB 和 LB）组中，对侧半球的 FC 增加，并与教育持续时间呈正相关。认知评估分数与 FC 和 BOLD 反应的簇系数相关（p<0.01）。
FC 的改变取决于儿童的发病年龄和听觉触觉训练，与听觉语言和记忆感知的增加有关。
