Eguchi Natsuki, Damyar Kimia, Alexander Michael, Dafoe Donald, Lakey Jonathan R T, Ichii Hirohito
Department of Surgery, University of California, Irvine, CA 92697, USA.
Department of Biomedical Engineering, University of California, Irvine, CA 92686, USA.
Antioxidants (Basel). 2022 May 24;11(6):1038. doi: 10.3390/antiox11061038.
Islet cell transplantation has become a favorable therapeutic approach in the treatment of Type 1 Diabetes due to the lower surgical risks and potential complications compared to conventional pancreas transplantation. Despite significant improvements in islet cell transplantation outcomes, several limitations hamper long-term graft survival due to tremendous damage and loss of islet cells during the islet cell transplantation process. Oxidative stress has been identified as an omnipresent stressor that negatively affects both the viability and function of isolated islets. Furthermore, it has been established that at baseline, pancreatic β cells exhibit reduced antioxidative capacity, rendering them even more susceptible to oxidative stress during metabolic stress. Thus, identifying antioxidants capable of conferring protection against oxidative stressors present throughout the islet transplantation process is a valuable approach to improving the overall outcomes of islet cell transplantation. In this review we discuss the potential application of antioxidative therapy during each step of islet cell transplantation.
与传统胰腺移植相比，胰岛移植因手术风险较低和潜在并发症较少，已成为治疗1型糖尿病的一种有利治疗方法。尽管胰岛移植结果有了显著改善，但由于在胰岛移植过程中胰岛细胞受到巨大损伤和损失，一些限制因素阻碍了移植胰岛的长期存活。氧化应激已被确定为一种普遍存在的应激源，会对分离的胰岛的活力和功能产生负面影响。此外，已经确定在基线时，胰腺β细胞的抗氧化能力降低，使其在代谢应激期间更容易受到氧化应激的影响。因此，确定能够对抗整个胰岛移植过程中存在的氧化应激源的抗氧化剂，是改善胰岛移植总体结果的一种有价值的方法。在这篇综述中，我们讨论了抗氧化治疗在胰岛移植各步骤中的潜在应用。
