Jo Sung Jun, Kim Kyeong Deok, Lim So Hee, Kim Jinseob, Kim Min Jung, Park Jae Berm, Lee Kyo Won
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
Department of Surgery, Inha University Hospital, Inha University School of Medicine, Incheon 22332, Korea.
Cancers (Basel). 2022 Jun 19;14(12):3020. doi: 10.3390/cancers14123020.
In retroperitoneal sarcoma (RPS), the change in the tumor grade from the primary tumor to the first local recurrence, and the effect of this change on prognosis, are unknown. The aim of this study is to analyze whether these changes affect the prognosis of RPS. Patients who underwent surgery for a first locally recurrent RPS at Samsung Medical Center from January 2001 to February 2020 were included. The pathologic features of primary and recurrent tumors were compared, and the outcomes were measured. A total of 49 patients were investigated. There were 25 patients with different grades of primary and recurrent tumors. The improving, stable, and worsening groups contained 16 (32.7%), 24 (49%), and 9 (18.3%) patients, respectively. There was no significant difference in the prognosis between the three groups. In the analyses of the factors that affect the OS, a high grade of the primary tumor ( = 0.023) and the size of the recurrent tumor ( = 0.032) were statistically significant in both univariate and multivariate analyses. In a factor analysis of the second LR, a high-grade recurrent tumor ( 0.032) was the only significant factor. There were tumor-grade changes between the primary tumor and recurrent tumor in RPS. However, the most important factor in prognosis is a high grade of the primary tumor.
在腹膜后肉瘤（RPS）中，肿瘤分级从原发肿瘤到首次局部复发的变化及其对预后的影响尚不清楚。本研究的目的是分析这些变化是否会影响RPS的预后。纳入了2001年1月至2020年2月在三星医疗中心接受首次局部复发性RPS手术的患者。比较原发肿瘤和复发性肿瘤的病理特征，并测量结果。共调查了49例患者。有25例患者的原发肿瘤和复发性肿瘤分级不同。改善组、稳定组和恶化组分别包含16例（32.7%）、24例（49%）和9例（18.3%）患者。三组之间的预后无显著差异。在影响总生存期的因素分析中，原发肿瘤的高分级（P = 0.023）和复发性肿瘤的大小（P = 0.032）在单因素和多因素分析中均具有统计学意义。在第二次局部复发的因素分析中，高分级复发性肿瘤（P = 0.032）是唯一的显著因素。RPS的原发肿瘤和复发性肿瘤之间存在肿瘤分级变化。然而，预后的最重要因素是原发肿瘤的高分级。
