Lombard Arnaud, Duffau Hugues
Department of Neurosurgery, Centre Hospitalier Universitaire of Liège, 4000 Liège, Belgium.
Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liège, 4032 Liège, Belgium.
Cancers (Basel). 2022 Jun 20;14(12):3025. doi: 10.3390/cancers14123025.
Diffuse low-grade gliomas (LGG) commonly affect young adults and display a slow evolution, with a life expectancy that can surpass 15 years, thanks to multimodal therapeutic management. Therefore, preservation of quality of life (QoL), including sexual health, is mandatory. We systematically searched available medical databases of Pubmed, Cochrane, and Scopus for studies that reported data on sexual activity or dysfunction (SD) in LGG patients. We analyzed results to determine incidence of SD and its association with QoL in this population. Three studies focused on SD incidence in patients presenting specifically LGG, or brain tumors including LGG. They comprised 124 brain tumor patients, including 62 LGG, with SD incidence ranging from 44 to 63%. SD was reported by more than 50% of interrogated women in the three studies. Regarding QoL, two out of the three studies found significant associations between SD and alterations of QoL parameters, particularly in the field of social and functional wellbeing. Finally, we discussed those results regarding methods of evaluation, inherent biases, and therapeutic implications regarding antiseizure medications and also planning of surgery, chemo-, and radiotherapy. Our review showed that SD is highly prevalent but still poorly studied in LGG patients. As those patients are usually young and enjoy an active life, there is a need to assess more systematically the occurrence of SD in clinical routine, in order to adapt cancer treatments accordingly, to manage actively these troubles, and finally to improve patients' QoL in the long run.
弥漫性低级别胶质瘤（LGG）通常影响年轻成年人，进展缓慢，由于多模式治疗管理，其预期寿命可超过15年。因此，包括性健康在内的生活质量（QoL）的维持至关重要。我们系统检索了PubMed、Cochrane和Scopus等医学数据库，以查找报告LGG患者性活动或性功能障碍（SD）数据的研究。我们分析结果以确定该人群中SD的发生率及其与QoL的关联。三项研究聚焦于特定LGG患者或包括LGG在内的脑肿瘤患者的SD发生率。这些研究共纳入124例脑肿瘤患者，其中62例为LGG患者，SD发生率在44%至63%之间。在这三项研究中，超过50%的受访女性报告了SD。关于QoL，三项研究中有两项发现SD与QoL参数改变之间存在显著关联，尤其是在社会和功能健康领域。最后，我们讨论了这些结果在评估方法、内在偏倚以及抗癫痫药物的治疗意义和手术、化疗及放疗计划方面的情况。我们的综述表明，SD在LGG患者中非常普遍，但研究仍然不足。由于这些患者通常年轻且生活活跃，有必要在临床常规中更系统地评估SD的发生情况，以便相应地调整癌症治疗方案，积极处理这些问题，并最终从长远角度改善患者的QoL。
