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复杂谱系 3 的起源和全球扩张。

Origin and Global Expansion of Complex Lineage 3.

机构信息

College of Veterinary Medicine, Sudan University of Science and Technology, P.O. Box 204 Hilat Kuku, Khartoum North 13321, Sudan.

Molecular and Experimental Mycobacteriology, Research Center Borstel, 23845 Borstel, Germany.

出版信息

Genes (Basel). 2022 May 31;13(6):990. doi: 10.3390/genes13060990.

DOI:10.3390/genes13060990
PMID:35741753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9222951/
Abstract

complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.

摘要

L3 型分枝杆菌（MTBC）菌株在结核病负担最高的世界区域中大量存在。为了研究该主要谱系的种群结构和全球多样性，我们分析了来自 5 大洲 38 个国家的 2682 株 L3 型菌株的数据集，采用 24 个基因座分枝杆菌间隔重复单元-可变数串联重复基因分型（MIRU-VNTR）和药敏试验。我们进一步对代表全球 L3 遗传多样性的 373 株菌株进行全基因组测序（WGS）和系统地理分析。祖先状态重建证实，L3 菌株的起源位于南亚，并进一步揭示了多次独立的传入事件到东北非和东非。本研究提供了对 L3 菌株全球多样性的系统了解，并报告了可能为评估新药/方案或疫苗候选物有效性的临床试验提供信息的系统地理变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/a8e5a8e4edd9/genes-13-00990-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/f79d25fe2d5f/genes-13-00990-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/953b7daf666c/genes-13-00990-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/fe6ad0f53633/genes-13-00990-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/2b39535b9f07/genes-13-00990-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/a8e5a8e4edd9/genes-13-00990-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/f79d25fe2d5f/genes-13-00990-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/953b7daf666c/genes-13-00990-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/fe6ad0f53633/genes-13-00990-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/2b39535b9f07/genes-13-00990-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50fe/9222951/a8e5a8e4edd9/genes-13-00990-g005.jpg

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