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宫颈癌新进展:从基础到临床。

New Advances in Cervical Cancer: From Bench to Bedside.

机构信息

PhD Course in "Translational Medicine and Oncology", Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University, 00185 Rome, Italy.

Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

出版信息

Int J Environ Res Public Health. 2022 Jun 9;19(12):7094. doi: 10.3390/ijerph19127094.

Abstract

Cervical cancer is the most common gynecologic malignancy and the fourth most common cancer in women worldwide. Over the last two decades, minimally invasive surgery (MIS) has emerged as the mainstay in the surgical management of early-stage cervical cancer, bringing advantages such as a lower operative morbidity and shorter hospital stay compared to open surgery, while maintaining comparable oncologic outcomes in numerous retrospective studies. Considering oncological patients, it is mandatory to assess the oncological outcomes and safety of this type of surgery. Moreover, there are different future outlooks on cervical cancer therapy, based on immunotherapy, target therapy, and poly-ADP-ribose polymerases (PARP) inhibitors in combination with each other, and in combination with standard chemotherapy and radiotherapy. The goal is to find an approach that is as personalized as possible.

摘要

宫颈癌是最常见的妇科恶性肿瘤,也是全世界女性中第四大常见的癌症。在过去的二十年中,微创手术(MIS)已成为早期宫颈癌手术治疗的主要方法,与开放手术相比,它具有较低的手术发病率和较短的住院时间,同时在许多回顾性研究中保持了相似的肿瘤学结果。对于肿瘤患者,必须评估这种手术的肿瘤学结果和安全性。此外,基于免疫疗法、靶向疗法和聚 ADP-核糖聚合酶(PARP)抑制剂的相互结合,以及与标准化疗和放疗的相互结合,宫颈癌治疗有不同的未来展望。目标是找到一种尽可能个性化的方法。

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