Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Department of Geriatrics, Medical Academy, Lithuanian University of Health Science, LT-44307 Kaunas, Lithuania.
Int J Environ Res Public Health. 2022 Jun 14;19(12):7309. doi: 10.3390/ijerph19127309.
As there is some evidence that the risk for Alzheimer's disease (AD) is partially attributable to environmental exposure to some metals and metalloids, we examined an association between AD and arsenic, chromium, and selenium in 53 AD patients and 217 controls. Urinary arsenic, blood chromium, and selenium were determined by inductively coupled plasma mass spectrometry. Logistic regression models calculating odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate AD association with arsenic, chromium, and selenium. In AD patients, urinary arsenic and blood chromium were significantly higher, while blood selenium was significantly lower compared to controls. Increased blood selenium was related to a significant decrease in the odds of AD after adjustment for risk factors. Blood selenium per 1 kg × 10/m × 10 increment was associated with 1.4 times lower risk of AD (OR = 0.71; 95% CI 0.58-0.87). A significant increase in the odds of AD associated with increased blood chromium was also seen in the adjusted model: the OR per 1 kg × 10/m × 10 chromium increment was 2.39 (95% CI 1.32-4.31). The association of urinary arsenic with the risk of AD was not significant. The data obtained provide evidence that selenium reduces the risk of Alzheimer's disease, while chromium increases it.
由于有一些证据表明阿尔茨海默病（AD）的风险部分归因于环境暴露于某些金属和类金属，因此我们研究了 AD 与砷、铬和硒在 53 名 AD 患者和 217 名对照中的相关性。通过电感耦合等离子体质谱法测定尿砷、血铬和血硒。使用逻辑回归模型计算比值比（OR）和 95%置信区间（CI）来估计 AD 与砷、铬和硒的相关性。与对照组相比，AD 患者的尿砷和血铬显著升高，而血硒显著降低。调整危险因素后，血硒增加与 AD 发生的几率显著降低相关。血硒每增加 1kg×10/m×10，AD 的风险降低 1.4 倍（OR=0.71；95%CI 0.58-0.87）。在调整模型中，还观察到血铬增加与 AD 发生几率显著增加相关：每增加 1kg×10/m×10 铬，OR 为 2.39（95%CI 1.32-4.31）。尿砷与 AD 风险的相关性没有统计学意义。获得的数据提供了证据表明，硒降低了阿尔茨海默病的风险，而铬增加了这种风险。
