Speit G, Vogel W
Mutat Res. 1979 Feb;59(2):223-9. doi: 10.1016/0027-5107(79)90161-1.
Intercalating dyes (acridine orange, proflavin and methylene blue) and drugs (chlorpromazine, promazine and chlorprothixene) were tested for their ability to induce sister-chromatid exchanges (SCEs) with and without photoactivation by visible light. Whereas in the dark all substances tested increased the frequency of SCEs, a superimposed effect of visible light on SCE formation was observed for the acridines proflavin and acridine orange, but not for the pheneothiazine derivatives methylene blue and chlorpromazine. These results are discussed in connection with the known mutagenic effects of these substances and with the factors that may be involved in SCE formation induced by intercalating molecules in the absence and presence of visible light.
对嵌入染料（吖啶橙、原黄素和亚甲蓝）及药物（氯丙嗪、丙嗪和氯普噻吨）进行了测试，以考察它们在有无可见光光活化情况下诱导姐妹染色单体交换（SCE）的能力。在黑暗中，所有测试物质均会增加SCE的频率，而对于原黄素和吖啶橙这两种吖啶类物质，观察到可见光对SCE形成有叠加效应，但对于吩噻嗪衍生物亚甲蓝和氯丙嗪则未观察到这种效应。结合这些物质已知的诱变效应以及在有无可见光情况下嵌入分子诱导SCE形成可能涉及的因素，对这些结果进行了讨论。
