Hart Odette, Xue Nicole, Davis-Havill Brittany, Pottier Mark, Prakash Minesh, Reimann Sascha-Akito, King Jasmin, Xu William, Khashram Manar
Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1010, New Zealand.
Department of Vascular and Endovascular Surgery, Waikato District Health Board, Hamilton 3204, New Zealand.
J Clin Med. 2022 Jun 9;11(12):3303. doi: 10.3390/jcm11123303.
The epidemiology of severe PAD, as characterized by short-distance intermittent claudication (IC) and chronic limb-threatening ischemia (CLTI), remains undefined in New Zealand (NZ). This was a retrospective observational cohort study of the Midland region in NZ, including all lower limb PAD-related surgical and percutaneous interventions between the 1st of January 2010 and the 31st of December 2021. Overall, 2541 patients were included. The mean annual incidence of short-distance IC was 15.8 per 100,000, and of CLTI was 36.2 per 100,000 population. The annual incidence of both conditions was greater in men. Women presented 3 years older with PAD (p < 0.001). Patients with short-distance IC had lower ipsilateral major limb amputation at 30 days compared to CLTI (IC 2, 0.3% vs. CLTI 298, 16.7%, p < 0.001). The 30-day mortality was greater in elderly patients (<65 years 2.7% vs. ≥65 years 4.4%, p = 0.049), but did not differ depending on sex (females 36, 3.7% vs. males 64, 4.1%, p = 0.787). Elderly age was associated with a worse survival for both short-distance IC and CLTI. There was a worse survival for females with CLTI. In conclusion, PAD imposes a significant burden in NZ, and further research is required in order to reduce this disparity.
以短距离间歇性跛行（IC）和慢性肢体威胁性缺血（CLTI）为特征的重度外周动脉疾病（PAD）的流行病学情况在新西兰（NZ）仍不明确。这是一项对新西兰中部地区的回顾性观察队列研究，涵盖了2010年1月1日至2021年12月31日期间所有与下肢PAD相关的外科手术和经皮介入治疗。总体纳入了2541名患者。短距离IC的年平均发病率为每10万人15.8例，CLTI为每10万人36.2例。两种情况的年发病率男性均更高。女性PAD患者发病年龄比男性大3岁（p<0.001）。与CLTI相比，短距离IC患者30天时同侧大肢体截肢率更低（IC组2例，0.3%；CLTI组298例，16.7%，p<0.001）。老年患者（<65岁2.7% vs.≥65岁4.4%，p = 0.049）30天死亡率更高，但在性别上无差异（女性36例，3.7%；男性64例，4.1%，p = 0.787）。高龄与短距离IC和CLTI患者的较差生存率相关。CLTI女性患者生存率更差。总之，PAD在新西兰造成了重大负担，需要进一步研究以减少这种差异。
